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Patients with a primary invasive melanoma are recommended to undergo excision of the primary lesion with a wide margin. There is evidence that less radical margins of excision may be just as safe. This is a randomised controlled trial of 1 cm versus 2 cm margin of excision of the primary lesion for adult patients with stage II primary invasive cutaneous melanomas (AJCC 8th edition) to determine differences in disease-free survival. A reduction in margins is expected to improve patient quality of life.
This study will determine whether there is a difference in disease-free survival rates for patients with primary cutaneous melanoma with Breslow thickness > 2mm or 1-2mm with ulceration (pT2b-pT4b, AJCC 8th edition), treated with either a 1cm excision margin or 2cm margin. The study is designed to be able to prove or disprove that there is no difference in risk of the tumour recurring around the scar or anywhere else in the body between the two groups of patients. If the study shows no risk of tumour recurrence then we will also be able to determine how much of an impact the narrower excision has on patients in terms of improved quality of life and reduced side effects from the surgery and melanoma disease. This trial will also evaluate and determine the economic impact of narrower excision margins on the health services and society in general.
Cutaneous Melanoma, Stage II
Wide Local Excision = 1cm Margin, Wide Local Excision = 2cm Margin
Melanoma Institute Australia
New South Wales
Not yet recruiting
Australia and New Zealand Melanoma Trials Group
Published on BioPortfolio: 2019-03-08T03:21:20-0500
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The edges of tissue removed in a surgery for assessment of the effectiveness of a surgical procedure in achieving the local control of a neoplasm and the adequacy of tumor removal. When the margin is negative or not involved by tumor (e.g., CANCER) it suggests all of the tumor has been removed by the surgery.
A fibrosarcoma of the skin, beginning most often as an indurated nodule that grows slowly and hence is often ignored until it grows large. Dermatofibrosarcomas show an extremely aggressive tendency to invade local surrounding tissue. They do not metastasize, however, even after multiple recurrences. About 50% will recur after simple incision; hence wide excision should be resorted to. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1356)
Removal of dental plaque and dental calculus from the surface of a tooth, from the surface of a tooth apical to the gingival margin accumulated in periodontal pockets, or from the surface coronal to the gingival margin.
Surgical excision of one or more lymph nodes. Its most common use is in cancer surgery. (From Dorland, 28th ed, p966)
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