Track topics on Twitter Track topics that are important to you
This is a longitudinal cohort study to estimate the accuracy of the schistosomiasis point-of-care circulating cathodic antigen (POC CCA) urine test for monitoring S. japonicum infection by enrolling individuals aged ≥2 years living in the selected households will be invited to participate in the study (pediatric <18 years old will be invited through their parent/guardian) at Lindu, Napu and Bada regions of Central Sulawesi of highest S. japonicum infection prevalence. This study will be conducted in two stages, in the first stage, participants will be recruited from 10 villages of highest S. japonicum infection prevalence. A futility analysis will be conducted after stage one. If a decision is made to proceed with stage 2, additional participants will be recruited.
Indonesia's plan for elimination of schistosomiasis by 2025 requires a better understanding of the factors associated with infection, effective epidemiologic monitoring, and optimization of diagnostic and treatment strategies. In settings of low prevalence such as Lindu, Napu and Bada regions of Central Sulawesi, an ultrasensitive technique to diagnose Schistosoma japonicum is needed. A diagnostic test that is efficient, accurate and easy to use would facilitate collection of reliable epidemiologic information and provide and effective means of assessing the impact of mass drug administration (MDA).
To estimate the accuracy of the schistosomiasis point-of-care circulating cathodic antigen (POC CCA) urine test for monitoring S. japonicum infection.
1. To update existing epidemiologic, risk factor and mapping of human, snail and animal infections.
2. To identify high infection risk areas with the updated data.
3. To assess correlations between spatial parameters and other risk factors related to human schistosome infections.
4. To assess rates of positive testing by POC-CCA rapid urine test, Kato Katz stool microscopies, serology, and molecular methods (PCR).
5. To evaluate the impact of abnormal urinary findings, i.e. hematuria and markers of urinary tract infections, on POC-CCA rapid urine test results.
6. To evaluate the efficacy of praziquantel administered through local primary health centers (Puskesmas).
7. To estimate the prevalence of soil transmitted helminth infections (STH), i.e. roundworms (Ascaris lumbricoides), whipworms (Trichuris trichiura), and hookworms (Necator americanus and Ancylostoma duodenale) in this population.
If the target enrollment includes 30 infected participants by Kato Katz multiple stool microscopies, with the assumption of 0.3% prevalence and estimated precision of ±15-20%, up to 10,000 participants will be needed.
Aged ≥2 Years in Schistosomiasis Affected Areas
POC-CCA rapid urine test
Donggala Research and Development (R&D) Center, Ministry of Health of Indonesia
Central Of Sulawesi
Not yet recruiting
Published on BioPortfolio: 2019-03-15T04:52:22-0400
The purpose of this study is to evaluate the use of a urine test strip in diagnose schistosoma mansoni in areas of Kenya where the rate of infections are low. The hypothesis is that the u...
Schistosomiasis and soil-transmitted helminhtiasis occur throughout the developing world and are most prevalent in the poorest communitites. These worms have been linked to several nutriti...
Schistosomiasis is a flatworm transmitted from freshwater snails to humans in the tropics. In addition to this infectious disease, tropical developing countries are faced with malnutrition...
Urinary schistosomiasis is a debilitating disease in Central Africa and pregnant women are frequently suffering from this condition. Mefloquine is currently investigated as preventive trea...
The clinical trial phase 2b is designed to assess the safety, the specific immune response and the anti-parasite effect of the active ingredient (protein + adjuvant) in healthy and then in...
A major hurdle in the elimination of urogenital schistosomiasis revealed: Identifying key gaps in knowledge and understanding of female genital schistosomiasis within communities and local health workers.
Urogenital schistosomiasis is endemic throughout Ghana with elevated infection levels in certain areas e.g. Lake Volta Region. While the primary focus of the national control program is on mass drug a...
The Kato-Katz (KK) technique is the mainstay mapping tool for the diagnosis of Schistosoma mansoni infection, despite showing poor sensitivity in cases of low-intensity infections. As an alternative, ...
The occurrence of elevated uranium levels in post-war areas raise concerns among populations, especially in areas affected by heavy bombardment and potential use of depleted uranium weapons. The aim o...
A national mapping of human schistosomiasis was conducted in Benin to provide the baseline epidemiological data required to implement the national strategy for schistosomiasis control and elimination ...
This study aimed to assess the association between exposure to chromium and neuropsychological development among children. A cross-sectional study was conducted with 393 children aged 6-11 years old r...
A person 65 through 79 years of age. For a person older than 79 years, AGED, 80 AND OVER is available.
A parasomnia characterized by a partial arousal that occurs during stage IV of non-REM sleep. Affected individuals exhibit semipurposeful behaviors such as ambulation and are difficult to fully awaken. Children are primarily affected, with a peak age range of 4-6 years.
A person 80 years of age and older.
A diagnostic test in which vitamin B12 is tagged with radioactive cobalt, taken orally, and gastrointestinal absorption is determined via measurement of the amount of radioactivity in a 24-hour urine collection.
Schistosomiasis caused by Schistosoma japonicum. It is endemic in the Far East and affects the bowel, liver, and spleen,
Benign Prostatic Hyperplasia (BPH) Erectile Dysfunction Urology Urology is the branch of medicine concerned with the urinary tract and diseases that affect it. Examples include urethritis, urethrostenosis and incontinence. Urology is a su...
Antiretroviral Therapy Clostridium Difficile Ebola HIV & AIDS Infectious Diseases Influenza Malaria Measles Sepsis Swine Flu Tropical Medicine Tuberculosis Infectious diseases are caused by pathogenic...