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This study will evaluate the use of free autologous dermal fat grafting to treat complex craniofacial wounds that have failed standard treatment and to understand how these grafts help the wounds heal. Half of the patients in this study will be randomly chosen to have free autologous dermal fat grafting (in addition to any other care required, such as antibiotics or surgery to clean the wound) to treat their complex craniofacial wounds. The other half of patients will receive standard care only, such as antibiotics or surgery to clean the wound, to treat their complex craniofacial wound.
A complex craniofacial wound is a wound on the head or face that will not heal, despite efforts to heal the wound with standard treatments, such as antibiotics and surgery to clean the wound. Currently, there are no good treatment options for these types of complex craniofacial wounds. This study will evaluate what happens when free autologous dermal fat grafting is used to help treat complex craniofacial wounds by evaluating the area where the graft was placed to better understand how these types of grafts function. Free autologous dermal fat grafting is the process of taking fat from under the outer layer of skin and moving it to another part of the body of the same individual. Although free autologous dermal fat grafts have been used for many decades in plastic and reconstructive surgery to help a variety of patients suffering from different problems, only one study has used them to help heal complex craniofacial wounds. This use of free autologous dermal fat grafting is not considered to be experimental or an investigational product by the US Food and Drug Administration (FDA). Still, the use of free autologous dermal fat grafting has not been formally evaluated to understand how these types of grafts help patients with complex craniofacial wounds.
Wound; Head, Multiple
Free autologous dermal fat graft, Standard care
Office of Craig R Dufresne, MD, PC
Not yet recruiting
Dufresne, Craig, MD, PC
Published on BioPortfolio: 2019-03-18T05:18:24-0400
This study will evaluate the use of free autologous dermal fat grafting to treat complex craniofacial wounds that have failed standard treatment and to understand how well these grafts wor...
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Microsurgical revascularization to improve intracranial circulation. It usually involves joining the extracranial circulation to the intracranial circulation but may include extracranial revascularization (e.g., subclavian-vertebral artery bypass, subclavian-external carotid artery bypass). It is performed by joining two arteries (direct anastomosis or use of graft) or by free autologous transplantation of highly vascularized tissue to the surface of the brain.
The minimum acceptable patient care, based on statutes, court decisions, policies, or professional guidelines.
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