Colchicine for the Treatment of Osteoarthritis of the Knee

2019-04-18 12:14:30 | BioPortfolio

Published on BioPortfolio: 2019-04-18T12:14:30-0400

Clinical Trials [4435 Associated Clinical Trials listed on BioPortfolio]

A Pharmacokinetic Study of Colchicine With an Oral Contraceptive

This study will evaluate the effect, if any, of twice daily dosing of colchicine 0.6 mg at steady state on the steady state pharmacokinetic profile of ethinyl estradiol and norethindrone (...

Colchicine for Amyotrophic Lateral Sclerosis

The study evaluates the effects of two different Colchicine doses (0.01mg/kg/day or 0.005 mg/kg/day) compared to placebo in Amyotrophic Lateral Sclerosis (ALS) patients. Disease progressio...

Colchicine for Patients With Chagas´ Disease( B1 Stage)

This study evaluate the addition of colchicine in the treatment of patients with Chagas´disease. Forty patients will receive colchicine while twenty patients will receive placebo

Effect of Low Dose ColchiciNe on the InciDence of POAF

The prior End-AF study by the same group showed that 1 mg of colchicine didn't decrease the incidence of AF after cardiac surgery. The current study, End-AF Low Dose Study, will test 0.5 m...

Pharmacokinetic Study With Colchicine in Healthy Volunteers

This open label, single group, sequential dose study will compare the single dose pharmacokinetics of colchicine 0.6 mg given orally to colchicine pharmacokinetics after 10 days of a stan...

PubMed Articles [8536 Associated PubMed Articles listed on BioPortfolio]

Comparison of the efficacy and safety of tocilizumab for colchicine-resistant or colchicine-intolerant familial Mediterranean fever: study protocol for an investigator-initiated, multicenter, randomized, double-blind, placebo-controlled trial.

Familial Mediterranean fever (FMF) is an inherited disorder caused by a number of mutations of the Mediterranean fever (MEFV) gene, coding a protein named pyrin that acts as a major regulatory compone...

A deeper look at pain variability and its relationship with the placebo response: results from a randomized, double-blind, placebo-controlled clinical trial of naproxen in osteoarthritis of the knee.

Previous studies have shown a robust correlation between variability of clinical pain scores and responsiveness to placebo (but not active drug) in pain studies, but explanations for these relationshi...

CGRP Blockade by Galcanezumab Was Not Associated with Reductions in Signs and Symptoms of Knee Osteoarthritis in a Randomized Clinical Trial.

This study tested whether galcanezumab, a humanized monoclonal antibody with efficacy against migraine, was superior to placebo for the treatment of mild or moderate osteoarthritis (OA) knee pain.

Time course of tolerance to the performance benefits of caffeine.

The ergogenic effect of acute caffeine ingestion has been widely investigated; however, scientific information regarding tolerance to the performance benefits of caffeine, when ingested on a day-to-da...

'Acute Flare-Ups' In Patients With, Or At High Risk Of, Knee Osteoarthritis: A Daily Diary Study With Case-Crossover Analysis.

To determine the natural history of flare-ups in knee osteoarthritis and their relation to physical exposures.

Medical and Biotech [MESH] Definitions

Three, alpha, beta, and gamma isomers of ultraviolet degradation products of colchicine that lack many of the physiological actions of the parent; used as experimental control for colchicine actions.

A cyclooxygenase inhibiting, non-steroidal anti-inflammatory agent (NSAID) that is well established in treating rheumatoid arthritis and osteoarthritis and used for musculoskeletal disorders, dysmenorrhea, and postoperative pain. Its long half-life enables it to be administered once daily.

Drugs administered orally and sequentially for contraceptive purposes.

Fixed drug combinations administered orally for contraceptive purposes.

An orally active synthetic progestational hormone used often in combinations as an oral contraceptive.

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