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Caffeine for Hypoxic-Ischemic Encephalopathy

2019-04-18 12:14:31 | BioPortfolio

Published on BioPortfolio: 2019-04-18T12:14:31-0400

Clinical Trials [1503 Associated Clinical Trials listed on BioPortfolio]

Prophylactic Versus Therapeutic Caffeine for Apnea of Prematurity

Investigators hypothesized that the timing of caffeine administration in either prophylaxis or treatment of apnea of prematurity will affect the apnea response to caffeine

Moderately Preterm Infants With Caffeine at Home for Apnea (MoCHA) Trial

The objective of this study is to evaluate the effect of continuing treatment with caffeine citrate in the hospital and at home in moderately preterm infants with resolved apnea of prematu...

Caffeine and Neurologic Recovery Following Surgery and General Anesthesia

The ongoing opioid epidemic is a public health crisis, and surgical patients are particularly vulnerable to opioid-dependency and related risks. Emerging data suggest that caffeine may red...

Early Caffeine in Preterm Neonates

This is a clinical trial which will investigate whether administration of caffeine, a respiratory stimulant, to preterm babies soon after birth can prevent the need for a breathing tube, o...

Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study

Apnea of prematurity is a common condition that is usually treated with methylxanthines. Methylxanthines are adenosine receptor blockers that have powerful influences on the central nervou...

PubMed Articles [2217 Associated PubMed Articles listed on BioPortfolio]

Caffeine content of pre-workout supplements commonly used by Australian consumers.

The stimulant properties of caffeine are often promoted in 'pre-workout' supplements (PWS) to assist with training, reduce the perception of fatigue, and for some brands, assist body fat loss. While m...

How to recognize caffeine overdose.

Caffeine is the most widely consumed stimulant in the world and can offer a variety of benefits when consumed in moderation. But consuming caffeine in extremely high amounts can lead to an overdose. T...

Caffeine and the eye.

Caffeine, a popular psychostimulant that acts as an adenosine receptor antagonist, is the most widely used drug in history, consumed daily by people worldwide. Knowledge of the physiological and patho...

The effect of caffeine on cutaneous postocclusive reactive hyperaemia.

Caffeine is reported to be the most widely used pharmacologically active substance. It causes mental stimulation and increases blood pressure. Acute systolic and diastolic blood pressure response to c...

Placental findings among newborns with hypoxic ischemic encephalopathy.

To determine if pre-specified placental abnormalities among newborns with hypoxic-ischemic encephalopathy (HIE) differ compared to newborns admitted to a NICU without encephalopathy.

Medical and Biotech [MESH] Definitions

An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.

A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.

Enzyme that catalyzes the first step of the tricarboxylic acid cycle (CITRIC ACID CYCLE). It catalyzes the reaction of oxaloacetate and acetyl CoA to form citrate and coenzyme A. This enzyme was formerly listed as EC 4.1.3.7.

An anthelmintic used primarily as the citrate in the treatment of filariasis, particularly infestations with Wucheria bancrofti or Loa loa.

A non-steroidal estrogen antagonist (as the 1:1 citrate) most commonly used as a research tool in animal studies.

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