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Approach for Optimizing Meropenem Therapy in Intubated and Mechanically-Ventilated, Adult Patients With Severe Gram-Negative Lower Respiratory Tract Infection

2019-04-17 12:55:22 | BioPortfolio

Summary

Antibacterial drugs are facing increasing limitations in terms of effectiveness due to emergence resistance. Improved antibacterial drug monitoring approaches are particularly needed in nosocomial infections occurring in ICU patients, including ventilator-associated pneumonia and ventilator-associated tracheobronchitis, where decreased susceptibility of the etiological organisms is observed worldwide and pharmacokinetic alterations frequently observed.

No routine drug monitoring is available for betalactams at the point of care in a useful time frame (i.e., within a few hours after having collected the blood specimens).

The purpose of this study is to compare MON4STRAT approach for reaching and maintaining a meropenem pre-determined PK-PD target when compared to conventional meropenem dose.

Study Design

Conditions

Lower Respiratory Tract Infection

Intervention

MON4STRAT Strategy, Control group

Location

Université Libre de Bruxelles
Bruxelles
Belgium
75013

Status

Recruiting

Source

Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-04-17T12:55:22-0400

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