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Penicillin Allergy Testing and Resensitization Rate

2019-05-13 18:25:16 | BioPortfolio

Summary

Penicillin is one of the earliest discovered antibiotics and a drug of choice for several infections. Up to 10 to 20% of all patients in clinical trial are labeled as penicillin allergic. Most of these patients do not have a true allergy but few have had it verified. Approximately 80% of patients with IgE-mediated penicillin allergy lose their sensitivity after 10 years. Several studies have been conducted denying the risk of sensitization following negative testing of penicillin allergy. Investigators have not had the same experience and have therefore decided to conduct a retrospective study review of 83 adult outpatients with a distant penicillin allergy label and evaluate outcomes of skin retesting six weeks following Drug Provocation Test and challenge.

Study Design

Conditions

Penicillin Allergy

Intervention

Behavioral allergy testing protocol

Location

CHR Metz Thionville
Thionville
Moselle
France
57100

Status

Completed

Source

Centre Hospitalier Régional Metz-Thionville

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-05-13T18:25:16-0400

Clinical Trials [1943 Associated Clinical Trials listed on BioPortfolio]

Allergy Testing of Patients Labeled as Penicillin Allergic

Patients labeled as penicillin allergic, rarely have this confirmed and being labeled as "penicillin allergic" is associated with increased health care costs, adverse effects and antibioti...

De-labeling of Patients With False Diagnosis of Penicillin Allergy

The purpose of this study is to estimate the prevalence of penicillin allergy, evaluate the diagnostic value of the allergologic work-up used in the study, and the health effects of penici...

Penicillin Skin Testing in Patients With History of Allergic Reactions to Betalactams

This study aims to compare the readings of skin testing results in patients with suspected penicillin allergy between in-house penicillin test preparation and commercial available penicill...

The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal

Currently it is estimated that at least 25 million people in the United States are labeled as penicillin allergic although less than 1.5 million of these are truly allergic. Although combi...

Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal in ICU Setting

Currently it is estimated that at least 25 million people in the United States are labeled as penicillin allergic although less than 1.5 million of these are truly allergic. Although combi...

PubMed Articles [9982 Associated PubMed Articles listed on BioPortfolio]

Multicenter Australian Study to Determine Criteria for Low- and High-Risk Penicillin Testing in Outpatients.

Recent single-center studies promote oral penicillin challenges, without skin testing, in patients with low risk/likelihood of true allergy. However, how best to define a low-risk penicillin allergy h...

A Closer Look at Penicillin Allergy History: Systematic Review and Meta-analysis of Tolerance to Drug Challenge.

True allergy to penicillin is rare, despite the high frequency with which it is reported. While most patients reporting penicillin allergy are not prone to anaphylaxis, it is not currently known what...

Diagnostic Testing for Penicillin Allergy: A Survey of Practices and Cost Perceptions.

Direct drug provocation testing may be safe for de-labelling the majority of inpatients with a penicillin allergy label and is associated with improved health and economic outcomes.

Penicillin Allergy Skin Testing as an Antibiotic Stewardship Intervention Reduces Alternative Antibiotic Exposures in Hematopoietic Stem Cell Transplant Recipients.

Antibiotic allergy de-labeling using penicillin allergy skin testing (PAST) can reduce the use and cost of alternative, non-β-lactam antibiotics in general inpatient populations. This strategy's role...

Medical and Biotech [MESH] Definitions

A method of treating an ALLERGY by administering ALLERGENS, in liquid formulation or tablets, to the ORAL MUCOSA under the tongue.

A medical specialty concerned with the hypersensitivity of the individual to foreign substances and protection from the resultant infection or disorder.

A selective histamine H1-receptor antagonist devoid of central nervous system depressant activity. The drug was used for ALLERGY but withdrawn due to causing LONG QT SYNDROME.

A vascular reaction of the skin characterized by erythema and wheal formation due to localized increase of vascular permeability. The causative mechanism may be allergy, infection, or stress.

The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.

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