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L-Citrulline Dose Finding Safety Study in MELAS

2019-05-19 19:37:15 | BioPortfolio

Published on BioPortfolio: 2019-05-19T19:37:15-0400

Clinical Trials [876 Associated Clinical Trials listed on BioPortfolio]

Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome

Patients with the MELAS syndrome experience devastating mental impairment. This study will evaluate the effectiveness of the drug dichloroacetate (DCA) to reduce the symptoms of MELAS.

L-Citrulline in Patients With Post-Polio Syndrome

The purpose of the study is to show that the intake of L-citrulline improves muscle function in patients with Post-Polio Syndrome.

Plasma Citrulline Concentration in Tropical Enteropathy

Citrulline is an amino acid produced in the intestine and in the liver, but the liver does not contribute significantly to circulating citrulline concentrations. The intestine is thus the ...

Effect of L-Citrulline on Vascular Function

The objective of this project is to determine the importance of peripheral vascular function on gait performance in older adults.

Immuno Nutrition by L-citrulline for Critically Ill Patients

The main objective of this study is to demonstrate that the only administration of L-citrulline, can improve immune functions in critically ill patients at high risk of nosocomial infectio...

PubMed Articles [4701 Associated PubMed Articles listed on BioPortfolio]

The Usefulness of Muscle Biopsy in Initial Diagnostic Evaluation of Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-Like Episodes.

The disease entity mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is characterized by an early onset of stroke-like episodes. MELAS is the most dominant subtype of ...

MELAS and macroangiopathy: A case report and literature review.

Mitochondrial encephalopathy, lactic acidosis and stroke-like episodes (MELAS) are thought to be rarely accompanied by macroangiopathy. We reported a case of MELAS that presented right distal internal...

Patients with MELAS not only require treatment of stroke-like episodes but a comprehensive individual and family management.

With interest we read the article by Hovsepian et al. about a 46 years-old female with MELAS syndrome due to the common variant m.3243A>G in the tRNA(Leu) gene [1]. The patient experienced a stroke-l...

L-Arginine Synthesis from L-Citrulline in Myeloid Cells Drives Host Defense against Mycobacteria In Vivo.

Immunonutrition as a therapeutic approach is rapidly gaining interest in the fight against infection. Targeting l-arginine metabolism is intriguing, considering this amino acid is the substrate for an...

Citrulline protects mice from experimental cerebral malaria by ameliorating hypoargininemia, urea cycle changes and vascular leak.

Clinical and model studies indicate that low nitric oxide (NO) bioavailability due in part to profound hypoargininemia contributes to cerebral malaria (CM) pathogenesis. Protection against CM pathogen...

Medical and Biotech [MESH] Definitions

A urea cycle enzyme that catalyzes the formation of orthophosphate and L-citrulline (CITRULLINE) from CARBAMOYL PHOSPHATE and L-ornithine (ORNITHINE). Deficiency of this enzyme may be transmitted as an X-linked trait. EC 2.1.3.3.

A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)

Conversion of ARGININE residues in proteins into CITRULLINE residues by PEPTIDYLARGININE DEIMINASES.

A family of ENZYMES that, in the presence of calcium ion, converts ARGININE to CITRULLINE in proteins.

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