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Evaluation of Halitosis After Treatment With Photodynamic Therapy

2019-06-10 00:42:23 | BioPortfolio

Summary

Halitosis is the term used to define an unpleasant odor emanating from the mouth. Some lung diseases, such as bronchiectasis, are among the extra-oral causes of this condition. However, no studies have evaluated the causes and treatment of halitosis in the population of adults with bronchiectasis. Methods and analysis: A randomized, controlled trial is proposed. The patients (n=80) with halitosis patients will be divided into two groups: G1- aPDT (Photodynamic Therapy) (n = 40); G2- tongue scraper, 10 teeth or more (n = 40). Halitosis will be evaluated based on the measurement of volatile sulfur compounds using gas chromatography. The participants will be randomized into two subgroups: treatment with photodynamic therapy (n = 40) or cleaning of the tongue with a tongue scraper (n = 40). After the treatments, a second evaluation will be performed, along with a microbiological analysis (qPCR) for the identification of the bacteria P. gingivalis and T. denticola. If the halitosis persists, the participants will received periodontal treatment The evaluation of halitosis and the microbiological analysis will be repeated. If the halitosis is resolved, the participants will return after three months for an additional evaluation. This protocol will determine the effectiveness of phototherapy regarding the reduction of halitosis in healthy older adults and those with bronchiectasis.

Description

A single-center, randomized, controlled, single-blind clinical trial was designed in accordance with the criteria recommended for interventional trials in the SPIRIT Statement. The project for the proposed study received approval from the Human Research Ethics Committee ofNove de Julho University(certificate number: 1057901).

Selection of individuals - characterization of sample - Two groups will be composed of adults in treatment at the dental clinic of Nove de Julho University. After verbal and written explanations of the study, those who agree to participate will sign a statement of informed consent approved by the Human Research Ethics Committee of Nove de Julho University. The study will be conducted in compliance with the precepts stipulated in the Declaration of Helsinki (revised in Fortaleza, Brazil, 2013).

Study Design

Conditions

Halitosis

Intervention

pdt experimental group, tongue scraper group

Status

Not yet recruiting

Source

University of Nove de Julho

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-06-10T00:42:23-0400

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