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Dupilumab Impact on Skin Resident Memory T Cells

2019-06-18 02:44:27 | BioPortfolio

Published on BioPortfolio: 2019-06-18T02:44:27-0400

Clinical Trials [2579 Associated Clinical Trials listed on BioPortfolio]

Diagnostic Equivalence of the Skin Prick Test Tape vs. Conventional Skin PrickTest

Testing of a new ready-to-use Tape in comparison to the currently used skin prick test for the diagnosis of allergies. Assessment of clinical equivalence of the SPT Tape for representative...

Study to Evaluate the Efficacy and Safety of Dupilumab Monotherapy in Pediatric Patients With Peanut Allergy

The primary objective of the study is to assess whether dupilumab as compared to placebo improves peanut protein tolerability, defined as an increase in the proportion of patients who safe...

Randomized Evaluation of Ten Allergy Skin Prick Test Devices

The goal of this study is to compare ten current and readily available FDA approved allergy skin prick devices to determine the most sensitive and specific product and methods used for the...

Accuracy Of Skin Prick Test Using In-house Wheat Extract For The Diagnosis Of IgE-mediated Wheat Allergy: A Pilot Study

Nowadays, commercial wheat extract is widely accessible, and is used for skin prick test for wheat allergy. However, commercial wheat extracted for skin prick test have less precise test r...

Comparison Between Local and Imported Skin Prick Testing Result of Rat and Mouse Allergen Extracts

In respiratory allergy patients, skin prick test results of local rat and mouse allergen extracts are not significant different from imported ones

PubMed Articles [31814 Associated PubMed Articles listed on BioPortfolio]

A review of dupilumab in the treatment of atopic diseases.

Dupilumab is a fully human monoclonal IgG4 antibody directed against the alpha subunit of the IL-4 receptor and prevents the signaling of IL-4 and IL-13, two type 2 cytokines known to be important dri...

Blocking type 2 inflammation by dupilumab does not control classic (Type 1-driven) allergic contact dermatitis in chronic hand eczema.

Dupilumab is an interleukin-4-receptor inhibitor indicated in recalcitrant moderate-to-severe atopic dermatitis (1). Atopic dermatitis (AD) is a predominantly type 2-axis immune disorder, whereas alle...

Side-by-side Comparison of Skin Biopsies and Skin Tape Stripping Highlights Abnormal Stratum Corneum in Atopic Dermatitis.

Skin biopsies are commonly used for the assessment of skin pathology in various skin diseases including atopic dermatitis (AD). However, due to the invasive nature of skin biopsies, many patients, par...

Dramatic improvement of generalized prurigo nodularis with dupilumab.

Prurigo nodularis (PN) is a common and debilitating skin condition with an unmet therapeutic need since there are no currently approved therapies and off-label treatments have limited efficacy. We des...

Sensitivity and specificity of the modified epicutaneous patch test in the diagnosis of respiratory allergy to Dermatophagoides pteronyssinus.

The skin prick test is recognized as the gold standard for the specific diagnosis of allergy.

Medical and Biotech [MESH] Definitions

A test to detect non-agglutinating ANTIBODIES against ERYTHROCYTES by use of anti-antibodies (the Coombs' reagent.) The direct test is applied to freshly drawn blood to detect antibody bound to circulating red cells. The indirect test is applied to serum to detect the presence of antibodies that can bind to red blood cells.

Duration of blood flow after skin puncture. This test is used as a measure of capillary and platelet function.

Work consisting of a clinical trial involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicine, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trial is characterized as a RANDOMIZED CONTROLLED TRIAL.

Clinical trials involving one or more test treatments, at least one control treatment, specified outcome measures for evaluating the studied intervention, and a bias-free method for assigning patients to the test treatment. The treatment may be drugs, devices, or procedures studied for diagnostic, therapeutic, or prophylactic effectiveness. Control measures include placebos, active medicines, no-treatment, dosage forms and regimens, historical comparisons, etc. When randomization using mathematical techniques, such as the use of a random numbers table, is employed to assign patients to test or control treatments, the trials are characterized as RANDOMIZED CONTROLLED TRIALS AS TOPIC.

Clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.

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