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Amyloidosis Typing Using Mass Spectrometry-based Proteomics: a New Accurate Tool for Difficult Typing

2019-06-18 02:44:26 | BioPortfolio

Published on BioPortfolio: 2019-06-18T02:44:26-0400

Clinical Trials [741 Associated Clinical Trials listed on BioPortfolio]

Monitoring of Early Disease Progression in Hereditary Transthyretin Amyloidosis

This study measures circulating, misfolded ATTR oligomers in asymptomatic ATTRm amyloidosis genetic carriers longitudinally over five years.

124I-p5+14 Injection Safety in Subjects With Systemic Amyloidosis

This is a single-center, exploratory, Phase 1 Positron Emission Tomography/x-ray Computed Tomography (PET/CT) imaging study to detect amyloidosis that will enroll patients with a confirmed...

Bortezomib for Immunoglobulin Light Chain(AL) Amyloidosis

Although the use of bortezomib has reported efficacy in amyloid light chain (AL) amyloidosis, the role of bortezomib with dexamethasone (BD) in the first-line treatment of patients with AL...

Recurrent AA Amyloidosis After Renal Transplantation

End-stage renal disease related to AA amyloidosis is well characterized but there is limited data concerning patient and graft outcomes after renal transplantation. The aim of this study i...

Effect of Low Dose Radiotherapy on ATTR Cardiac Amyloidosis : a Proof of Concept Study

Cardiac amyloidosis is responsible for significant morbidity associated with heart failure, and carries a poor prognosis. Currently there are very limited treatment options for this condit...

PubMed Articles [19141 Associated PubMed Articles listed on BioPortfolio]

An unusual case of Aβ2M amyloid deposition in bladder cancer in a non-dialysis patient.

β2-microglobulin-related (Aβ2M) amyloidosis (dialysis-associated amyloidosis) is a common complication in long-term dialysis patients. An increased concentration of β2-microgloblin (β2-m) in the s...

Noncontrast Magnetic Resonance for the Diagnosis of Cardiac Amyloidosis.

This study aimed to assess the diagnostic use of native T1 to detect cardiac amyloidosis (CA) in a large prospective cohort of patients referred for suspected systemic amyloidosis.

Experimental model of oral transmissible AA amyloidosis in quails.

In poultry and zoo birds, mass outbreaks of amyloid A (AA) amyloidosis are often reported, and horizontal transmission is concerned as one of the causes. However, oral transmission of avian AA amyloid...

Prevalence and clinical implications of t(11;14) in patients with amyloid light-chain amyloidosis with or without concurrent multiple myeloma.

According to fluorescent in situ hybridization, t(11;14) is the most common cytogenetic abnormality in amyloid light-chain (AL) amyloidosis, but its prevalence in patients with AL amyloidosis and conc...

Prognostic impact of light-chain and transthyretin-related categories in cardiac amyloidosis: a systematic review and meta-analysis.

Light-chain amyloidosis and transthyretin-related amyloidosis (wild-type and mutated) are three main types of systemic amyloidosis associated with a clinically relevant cardiac involvement. In this st...

Medical and Biotech [MESH] Definitions

Diseases in which there is a familial pattern of AMYLOIDOSIS.

A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.

An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.

A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.

Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.

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