a Clinical Trial of Efficacy and Safety of the Holistic Treatment of Young High-risk Multiple Myeloma Patients

2019-07-11 09:17:51 | BioPortfolio


The clinical trial was conducted in a cohort of young, high-risk myeloma patients who were designed to receive a combination of high-dose chemotherapy with allogeneic or autologous hematopoietic stem cell transplantation. The objective was to assess the progression free survival (PFS), overall survival (OS),and overall response rate (ORR) of the overall treatment.


50 cases of HR-NDMM patients were divided into two groups nonrandomizedly. TE group received hematopoietic stem cell transplantation after induction therapy. Allo-sct for the young patients with suitable donors, Asct for the others. TNE group received consolidation therapy after induction therapy. All patients received PI-based maintenance therapy.

Study Design


Multiple Myeloma


Allogeneic Hematopoietic Stem Cell Transplantation, Autologous Hematopoietic Stem Cell Transplantation x 1 or x 2, Melphalan Given IV, Fludarabine Injection, PI and dexamethasone as maintenance therapy, PI+IMids+Dexamethasone as Consolidated Chemotherapy


Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Sciences




Institute of Hematology & Blood Diseases Hospital

Results (where available)

View Results


Published on BioPortfolio: 2019-07-11T09:17:51-0400

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Medical and Biotech [MESH] Definitions

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