Localized,Diffuse Vocal Folds Irregularites

2019-07-09 08:12:42 | BioPortfolio


simple combination of functional investigation, in form of laryngostroboscopy, together with conventional histopathological examination, provides a highly sensitive method in differential diagnosis of undiagnosed vocal folds irregularites


Vocal folds irregularites often manifest as mucosal surface changes of leukoplakia, erythroplakia, or erythroleukoplakia. These gross mucosal changes may represent benign, premalignant, or malignant entities as they correspond to large spectrum of lesions ranging from simple totally benign keratosis with or without atypia up to invasive carcinoma. It is commonly encountered in the laryngology clinic and presents diagnostic and therapeutic challenges. Also, clinicians are tasked with understanding the nature of the lesions as well as functional consequences associated with the disease or its treatment.

The incidence of dysplasia within leukoplakic lesions approximates 50%. The rate of conversion to squamous cell carcinoma is contingent on the extent and/or degree of dysplasia. The vocal fold leukoplakia management remains challenging, and there is no unified surgical indication or guideline. The patient who suffers from vocal fold leukoplakia sometime need surgery, while some others do not need positive intervene, either nonsurgical or surgical. The laryngoscopic image is the major evidence to make the laryngologist suggest the patient to have a surgical or conservative treatment. However, there is no standard classification of the morphology of vocal fold leukoplakia in the literature.

Laryngostroboscopy is the most important tool for functional investigation in laryngological and phoniatric diagnosis. Stroboscopic evaluation mjb allows early detection of infiltrative processes of the vocal folds. Previous studies that tested exfoliative cytology, or brush biopsy provided a helpful tool, but, recourse of biopsies under general anesthesia lead to scarring of the vocal folds with consecutive voice impairment. Having encountered this problem, we present a proposal that refers to laryngostroboscopic examination combined with histopathology to put a differential diagnosis for these undiagnosed lesions.

Study Design


Vocal Cord Neoplasm


laryngostroboscopy and histoh-pathology


Not yet recruiting


Assiut University

Results (where available)

View Results


Published on BioPortfolio: 2019-07-09T08:12:42-0400

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Medical and Biotech [MESH] Definitions

A pair of cone-shaped elastic mucous membrane projecting from the laryngeal wall and forming a narrow slit between them. Each contains a thickened free edge (vocal ligament) extending from the THYROID CARTILAGE to the ARYTENOID CARTILAGE, and a VOCAL MUSCLE that shortens or relaxes the vocal cord to control sound production.

A disorder characterized by an intermittent abnormal VOCAL CORDS movement toward the midline during inspiration or expiration resulting in upper AIRWAY OBSTRUCTION.

Congenital or acquired paralysis of one or both VOCAL CORDS. This condition is caused by defects in the CENTRAL NERVOUS SYSTEM, the VAGUS NERVE and branches of LARYNGEAL NERVES. Common symptoms are VOICE DISORDERS including HOARSENESS or APHONIA.

The process of producing vocal sounds by means of VOCAL CORDS vibrating in an expiratory blast of air.

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