Topics

Blueberry Study Aimed at Improving Cognition and Peripheral Blood Flow

2019-07-16 10:38:52 | BioPortfolio

Summary

Blueberries are rich in the content of a variety of biologically active chemicals that contribute to their health properties. The consumption of blueberries has beneficial effects on vascular function and brain health and function. Blueberries are present in human diet in a number of forms, but the investigator do not know which form is best for health and why people respond differently to eating blueberries.

The aim of the present study is to assess the effects of 1 week's supplementation of whole blueberries or freeze-dried blueberry powder or encapsulated blueberry components on vascular function and brain health and function. Investigators will then categorise participants as those who have large effects of the intervention (responders) and those that don't show much effect at all (non-responders). Then the investigators will look into the role that genes play in this response and determine if metabolism is similar in these groups of participants. Any changes in participants' brain health and vascular function will be linked to these metabolic and genomic pathways, and this will help the investigators to further understand how blueberry consumption can benefit human health.

Description

Study design: The present study will supply either 160 g of fresh whole blueberry (4 handful portion) or 20 g of freeze-dried blueberry powder (measured with tablespoon provided; equivalent to 160 g of whole fresh blueberry), or placebo capsule with only microcrystalline cellulose (approx. 10 g, they will be blinded that this is encapsulated blueberry extract components) to 80 subjects on separate occasions with age range of 18-60 years old for 1 week with 1 week of washout period. Fresh blueberries will be purchased from local supermarkets; freeze-dried blueberry powder will be purchased from Lio-Licious freeze-dried fruits range; the microcrystalline cellulose will be purchased from Blackburn Distributions. There is no outside interest that could constitute commercial conflict of interest.

Methodology and sampling strategy: a randomised crossover design will be implemented. The study is a quantitative experiment and participants will be recruited through opportunity sampling.

Data collection: On each visit, cognition data will be obtained from computerised testing system COMPASS. Blood pressure will be obtained using fully automatic oscillometric device. On visits 2-7, PWV value is obtained by SphygmoCor; untargeted metabolomics and genomic data will be obtained from blood and urine sample collection.

For data analysis: The identification of responders to the treatments will be done by the calculation of response level first: response level = (change from baseline score/baseline score) x 100%. The calculated percentage will be used to characterise subjects from lowest response to highest response level. The association among -omics biomarkers and cognitive tests/endothelial parameters, lipid status under each treatment will be analysed using linear regression models after adjusting for confounding factors like age. Pathway analysis will be used to identify metabolic pathways that characterise responders and non-responders. Pathways will be identified using discriminatory metabolites from metabolomics and SNP analysis.

Study Design

Conditions

Vascular Stiffness

Intervention

Blueberries, Blueberry powder, Blueberry components capsules

Location

Northumbria University
Newcastle upon Tyne
Tyne And Wear
United Kingdom
NE1 8ST

Status

Recruiting

Source

Northumbria University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-07-16T10:38:52-0400

Clinical Trials [1437 Associated Clinical Trials listed on BioPortfolio]

Effect of Blueberries on Bone Turnover

This study uses a bone labeled calcium tracer methodology to compare the dose response effect of blueberry consumption on calcium retention and bone loss. Post menopausal women will receiv...

Effects of Blueberry on Gut Microbiota and Metabolic Syndrome

There is growing evidence that nutritional intervention with dietary polyphenols can positively modulate the gut microbiota to improve cardiometabolic health. Whether the beneficial effect...

The Effect of Blueberries on Enhancing Insulin Sensitivity in Humans

The purpose of this study is to evaluate the effect of blueberry powder on insulin sensitivity in obese, non-diabetic, and insulin resistant subjects. The investigators hypothesized that s...

Impact of Blueberry Consumption on Gastrointestinal Health

This study will evaluate the impact of blueberry consumption on markers of gastrointestinal health including gut microbiota, intestinal permeability, and gut-derived inflammation in those ...

An Investigation Into the Effects of Blueberry Anthocyanin on Cognitive Functioning and Mood Adolescents.

The purpose of this study is to determine whether a 4-week dietary intervention with wild blueberry powder can have an effect on cognitive performance in participants aged between 13-17.

PubMed Articles [4865 Associated PubMed Articles listed on BioPortfolio]

Blueberry extract attenuates doxorubicin-induced damage in H9c2 cardiac cells .

The objective of this study was to analyze the cardioprotective roles of 3 wild blueberry genotypes and one commercial blueberry genotype by measuring markers of oxidative stress and cell death in H9c...

The effect of blueberry interventions on cognitive performance and mood: a systematic review of randomized controlled trials.

Blueberries are rich in polyphenols that may be beneficial to cognitive performance and mood. The aim of this systematic review was to evaluate randomized controlled trials investigating the effects o...

Isolation and Characterization of Blueberry Polyphenolic Components and Their Effects on Gut Barrier Dysfunction.

Highbush blueberries contain anthocyanins and proanthocyanidins that have antimicrobial and anti-inflammatory bioactivities. We isolated and characterized three polyphenolic fractions, a total polyphe...

Circulating anthocyanin metabolites mediate vascular benefits of blueberries: insights from randomized controlled trials, metabolomics, and nutrigenomics.

Potential health benefits of blueberries may be due to vascular effects of anthocyanins which predominantly circulate in blood as phenolic acid metabolites. We investigated which role blueberry anthoc...

Effect of ethyl oleate pretreatment on blueberry ( L.): drying kinetics, antioxidant activity, and structure of wax layer.

Blueberry belongs to the genus , which is rich in a variety of biologically active components beneficial to the human body. Drying of blueberry is a slow and energy-intensive process because of its wa...

Medical and Biotech [MESH] Definitions

Several species of the genus Vaccinium which produce the edible blueberry fruit.

Several plant species of the genus VACCINIUM known for the edible blueberry fruit.

A large and diverse order of dicotyledonous flowering plants in the subclass DILLENIIDAE. Most members have weakly fused petals and radially symmetric flowers which form fruit capsules and thin seed coats. Members also contain IRIDOIDS, compounds which protect against herbivores. Common examples of the ericales are economically important species such as TEA, PERSIMMON, BLUEBERRY, BRAZIL NUTS, azalea, CRANBERRIES, and RHODODENDRON.

Loss of vascular ELASTICITY due to factors such as AGING; and ARTERIOSCLEROSIS. Increased arterial stiffness is one of the RISK FACTORS for many CARDIOVASCULAR DISEASES.

An envelope of loose gel surrounding a bacterial cell which is associated with the virulence of pathogenic bacteria. Some capsules have a well-defined border, whereas others form a slime layer that trails off into the medium. Most capsules consist of relatively simple polysaccharides but there are some bacteria whose capsules are made of polypeptides.

More From BioPortfolio on "Blueberry Study Aimed at Improving Cognition and Peripheral Blood Flow"

Quick Search

Relevant Topics

Blood
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Vascular
Vascular relates to blood vessels (Oxford Medical Dictionary) and can be used to describe the supply of blood, a disease affecting the blood vessels or molecules associated with these structures. For example, <!--LGfEGNT2Lhm-->atherosclerosis ...


Searches Linking to this Trial