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O2 Transport and Utilization in Health and Lung Disease

2019-07-16 10:38:55 | BioPortfolio

Summary

Skeletal muscle dysfunction is a frequent and clinically relevant systemic manifestation of Chronic Pulmonary Obstructive Disease (COPD), which is still poorly understood. Therefore, the focus of this study is on the role of a deficit in tetrahydrobiopterin and nitric oxide synthase uncoupling induced by chronic oxidative stress on metabolic and vascular abnormalities in skeletal muscle of patients suffering from COPD.

Description

The purpose of this study is to assess the efficacy of supplementation with tetrahydrobiopterin (BH4) for improving vascular and muscle function in patients with COPD and healthy controls.

Study Design

Conditions

COPD

Intervention

Tetrahydrobiopterin, Placebo oral tablet

Location

Institute of Applied Life Sciences
Amherst
Massachusetts
United States
01003

Status

Not yet recruiting

Source

University of Massachusetts, Amherst

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-07-16T10:38:55-0400

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