O2 Transport and Utilization in Health and Lung Disease

2019-07-16 10:38:55 | BioPortfolio


Skeletal muscle dysfunction is a frequent and clinically relevant systemic manifestation of Chronic Pulmonary Obstructive Disease (COPD), which is still poorly understood. Therefore, the focus of this study is on the role of a deficit in tetrahydrobiopterin and nitric oxide synthase uncoupling induced by chronic oxidative stress on metabolic and vascular abnormalities in skeletal muscle of patients suffering from COPD.


The purpose of this study is to assess the efficacy of supplementation with tetrahydrobiopterin (BH4) for improving vascular and muscle function in patients with COPD and healthy controls.

Study Design




Tetrahydrobiopterin, Placebo oral tablet


Institute of Applied Life Sciences
United States


Not yet recruiting


University of Massachusetts, Amherst

Results (where available)

View Results


Published on BioPortfolio: 2019-07-16T10:38:55-0400

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