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Neoantigen-based Personalized DNA Vaccine Combined With Immune Checkpoint Blockade Therapy in Patients With Newly Diagnosed, Unmethylated Glioblastoma

2019-07-17 10:05:16 | BioPortfolio

Summary

This is a single institution, open-label, multi-arm, study assessing the safety, feasibility, and immunogenicity of a personalized neoantigen-based vaccine combined with immune checkpoint inhibitors in subjects with newly diagnosed, unmethylated glioblastoma.

Study Design

Conditions

Glioblastoma

Intervention

Nivolumab, Ipilimumab, Personalized neoantigen DNA vaccine, CELLECTRA®2000 EP Device, Plasmid encoded IL-12

Location

Washington University School of Medicine
Saint Louis
Missouri
United States
63110

Status

Not yet recruiting

Source

Washington University School of Medicine

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-07-17T10:05:16-0400

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Medical and Biotech [MESH] Definitions

A combined vaccine used to prevent infection with diphtheria and tetanus toxoid. This is used in place of DTP vaccine (DIPHTHERIA-TETANUS-PERTUSSIS VACCINE) when PERTUSSIS VACCINE is contraindicated.

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