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This is a FIH, open-label, dose escalation, phase I clinical trial to assess the safety and immunogenicity of the candidate ChAdOx1 Zika vaccine in healthy volunteers given as a standalone vaccine or in coadministration with ChAdOx1 Chik. Both vaccines will be administered intramuscularly.
Volunteers will be recruited and vaccinated at the Centre for Clinical Vaccinology and Tropical Medicine (CCVTM), Oxford. There will be 7 study groups and a total of 57 volunteers will be enrolled. Groups 1-3 will receive ChAdOx1 Zika alone. Groups 4-7 will receive a co-administration of ChAdOx1 Zika and ChAdOx1 Chik administered contralaterally. Staggered enrolment will apply for the first three volunteers within each group.
ChAdOx1 Zika, ChAdOx1 Zika, ChAdOx1 Chik
CCVTM, University of Oxford, Churchill Hospital
Not yet recruiting
University of Oxford
Published on BioPortfolio: 2019-07-16T10:38:49-0400
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At the end of 2015, the first cases of Zika were identified in southern Mexico. During 2016, Zika spread as an outbreak to a large part of the country's coastal zones.
The risk of Zika virus (ZIKV) infection during pregnancy depends on the incidence of the disease, which is highly variable in different affected geographic areas (
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We characterized natural vertical transmission of Zika virus in pools of Aedes aegypti larvae hatched from eggs collected in Jojutla, Morelos, Mexico. Of the 151 pools analyzed, 17 tested positive for...
An arbovirus in the FLAVIVIRUS genus of the family FLAVIVIRIDAE. Originally isolated in the Zika Forest of UGANDA it has been introduced to Asia and the Americas.
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In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...
A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe, its toxins or one ...