Safety and Immunogenicity of a Candidate ZIKV Vaccine (ZIKA001)

2019-07-16 10:38:49 | BioPortfolio


This is a FIH, open-label, dose escalation, phase I clinical trial to assess the safety and immunogenicity of the candidate ChAdOx1 Zika vaccine in healthy volunteers given as a standalone vaccine or in coadministration with ChAdOx1 Chik. Both vaccines will be administered intramuscularly.


Volunteers will be recruited and vaccinated at the Centre for Clinical Vaccinology and Tropical Medicine (CCVTM), Oxford. There will be 7 study groups and a total of 57 volunteers will be enrolled. Groups 1-3 will receive ChAdOx1 Zika alone. Groups 4-7 will receive a co-administration of ChAdOx1 Zika and ChAdOx1 Chik administered contralaterally. Staggered enrolment will apply for the first three volunteers within each group.

Study Design




ChAdOx1 Zika, ChAdOx1 Zika, ChAdOx1 Chik


CCVTM, University of Oxford, Churchill Hospital
United Kingdom


Not yet recruiting


University of Oxford

Results (where available)

View Results


Published on BioPortfolio: 2019-07-16T10:38:49-0400

Clinical Trials [58 Associated Clinical Trials listed on BioPortfolio]

A Safety and Efficacy Study of ChAdOx1 LS2

The purpose of this study is to assess the safety, immunogenicity and efficacy of the candidate malaria vaccine ChAdOx1 LS2. Healthy adult volunteers will be recruited and vaccinated in O...

EMaBS TB Vaccine Study

The study will commence with a dose-escalation and age de-escalation study in healthy adults and adolescents in Uganda, focussing on ChAdOx1 85A, to provide safety data for ChAdOx1 85A in ...

Safety and Immunogenicity of a Candidate CHIKV Vaccine (CHIK001)

A phase I dose escalation study to assess the safety and immunogenicity of the candidate vaccine ChAdOx1 Chik in healthy volunteers. Volunteers will be recruited and vaccinated in Oxford,...

Understanding Excretion and Infectivity of Zika Virus in Semen During and After Infection

In this prospective observational study the investigators will report on 20 male subjects with proven WHO-classification Zika infection. These subjects will be followed up for a maximum of...

Phase I, Open-label, Dose-ranging Study of GLS-5700 in Healthy Volunteers

The clinical trial will assess the safety, tolerability, and immunogenicity of GLS-5700. GLS-5700 is a synthetic DNA plasmid vaccine against the Zika virus. ZIKA-001 is the first in man cl...

PubMed Articles [274 Associated PubMed Articles listed on BioPortfolio]

Zika virus: Epidemiological surveillance of the Mexican Institute of Social Security.

At the end of 2015, the first cases of Zika were identified in southern Mexico. During 2016, Zika spread as an outbreak to a large part of the country's coastal zones.

Zika virus during pregnancy: From maternal exposure to congenital Zika virus syndrome.

The risk of Zika virus (ZIKV) infection during pregnancy depends on the incidence of the disease, which is highly variable in different affected geographic areas (

Long-term circulation of Zika virus in Thailand: an observational study.

Little is known about the historical and current risk of Zika virus infection in southeast Asia, where the mosquito vector is widespread and other arboviruses circulate endemically. Centralised Zika v...

Low seroprevalence rates of Zika virus in Kuala Lumpur, Malaysia.

Zika virus (ZIKV) is believed to be endemic in Southeast Asia. However, there have been few Zika cases reported to date in Malaysia, which could be due to high pre-existing levels of population immuni...

Natural Vertical Transmission of Zika Virus in Larval Aedes aegypti Populations, Morelos, Mexico.

We characterized natural vertical transmission of Zika virus in pools of Aedes aegypti larvae hatched from eggs collected in Jojutla, Morelos, Mexico. Of the 151 pools analyzed, 17 tested positive for...

Medical and Biotech [MESH] Definitions

An arbovirus in the FLAVIVIRUS genus of the family FLAVIVIRIDAE. Originally isolated in the Zika Forest of UGANDA it has been introduced to Asia and the Americas.

A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, however, may be associated with other neurological and autoimmune complications (e.g., GUILLAIN-BARRE SYNDROME; and MICROCEPHALY).

More From BioPortfolio on "Safety and Immunogenicity of a Candidate ZIKV Vaccine (ZIKA001)"

Quick Search

Relevant Topics

Clincial Trials
In a clinical trial or interventional study, participants receive specific interventions according to the research plan or protocol created by the investigators. These interventions may be medical products, such as drugs or devices; procedures; or change...

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism, and is often made from weakened or killed forms of the microbe, its toxins or one ...

Searches Linking to this Trial