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Safety and Immunogenicity of a Candidate ZIKV Vaccine (ZIKA001)

2019-07-16 10:38:49 | BioPortfolio

Summary

This is a FIH, open-label, dose escalation, phase I clinical trial to assess the safety and immunogenicity of the candidate ChAdOx1 Zika vaccine in healthy volunteers given as a standalone vaccine or in coadministration with ChAdOx1 Chik. Both vaccines will be administered intramuscularly.

Description

Volunteers will be recruited and vaccinated at the Centre for Clinical Vaccinology and Tropical Medicine (CCVTM), Oxford. There will be 7 study groups and a total of 57 volunteers will be enrolled. Groups 1-3 will receive ChAdOx1 Zika alone. Groups 4-7 will receive a co-administration of ChAdOx1 Zika and ChAdOx1 Chik administered contralaterally. Staggered enrolment will apply for the first three volunteers within each group.

Study Design

Conditions

Zika

Intervention

ChAdOx1 Zika, ChAdOx1 Zika, ChAdOx1 Chik

Location

CCVTM, University of Oxford, Churchill Hospital
Oxford
United Kingdom
OX3 7LE

Status

Not yet recruiting

Source

University of Oxford

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-07-16T10:38:49-0400

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Medical and Biotech [MESH] Definitions

An arbovirus in the FLAVIVIRUS genus of the family FLAVIVIRIDAE. Originally isolated in the Zika Forest of UGANDA it has been introduced to Asia and the Americas.

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