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Advanced GC Multi-omic Characterization in EU and CELAC Populations

2019-07-16 10:38:50 | BioPortfolio

Summary

Observational study (cohort type) of advanced GC patients that will be recruited prospectively to study biological factors associated with the disease and relevant clinical outcomes.

Description

Despite of multiple attempts to improve treatment in recent decades, none strategies has improved prognosis in locally advanced stage III and IV GC. A therapeutic approach to GC based on current histological and image criteria (Tumour Node Metastasis -TNM- stage) is insufficient. Although multiple targeted agents are currently under investigation, so far, only trastuzumab and ramucirumab have demonstrated efficacy in advanced GC and have a regulatory approval. For this reason, the identification of specific targets that could be susceptible for drug inhibition, is an urgent requirement. Moreover, most studies and current international databases on late-stage/advanced GC are largely based on Asian populations, in sharp contrast tumour biology and genome of EU or CELAC populations remain poorly known.

The primary objective of this study are to:

- Identify the risk factors associated with each GC case and the relation with the different "omic" signatures.

- Determine the risk factors or the combination of them that are related to advanced GC and its association with the clinical outcomes under study.

- Determine the multiple causes that could explain GC diagnosis delay.

Study Design

Conditions

Gastric Cancer

Status

Not yet recruiting

Source

Fundación para la Investigación del Hospital Clínico de Valencia

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-07-16T10:38:50-0400

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