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Observational study (cohort type) of advanced GC patients that will be recruited prospectively to study biological factors associated with the disease and relevant clinical outcomes.
Despite of multiple attempts to improve treatment in recent decades, none strategies has improved prognosis in locally advanced stage III and IV GC. A therapeutic approach to GC based on current histological and image criteria (Tumour Node Metastasis -TNM- stage) is insufficient. Although multiple targeted agents are currently under investigation, so far, only trastuzumab and ramucirumab have demonstrated efficacy in advanced GC and have a regulatory approval. For this reason, the identification of specific targets that could be susceptible for drug inhibition, is an urgent requirement. Moreover, most studies and current international databases on late-stage/advanced GC are largely based on Asian populations, in sharp contrast tumour biology and genome of EU or CELAC populations remain poorly known.
The primary objective of this study are to:
- Identify the risk factors associated with each GC case and the relation with the different "omic" signatures.
- Determine the risk factors or the combination of them that are related to advanced GC and its association with the clinical outcomes under study.
- Determine the multiple causes that could explain GC diagnosis delay.
Not yet recruiting
Fundación para la Investigación del Hospital Clínico de Valencia
Published on BioPortfolio: 2019-07-16T10:38:50-0400
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In the original publication of this article, Fig. 2 was published incorrectly. The correct Fig. 2 is given in this correction.
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That portion of the stomach remaining after gastric surgery, usually gastrectomy or gastroenterostomy for cancer of the stomach or peptic ulcer. It is a common site of cancer referred to as stump cancer or carcinoma of the gastric stump.
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Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...