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Biodistribution&Pharmacokinetic of Position Emission Tomography(PET) Radiopharmaceutical 18F C SNAT4

2019-07-18 10:31:17 | BioPortfolio

Summary

Primary Objectives

- Determine the biodistribution of [18F]-C-SNAT4 in 5 healthy volunteers. Secondary Objectives

- Determine the dosimetry of [18F]-C-SNAT4 PET in healthy volunteers and patients with lung cancer.

- Determine the acute toxicity of [18F]-C-SNAT4 PET in healthy volunteers and patients with lung cancer.

- Determine whether uptake in [18F]-C-SNAT4 PET imaging is significantly different in tumor and corresponding contralateral noncancer tissue in patients with lung cancer (tested by Wilcoxon test) before the therapy.

- Determine/verify the safety profile of the [18F]-C-SNAT4 radiotracer, as an imaging agent in patients with lung cancer.

- Determine the time of maximal [18F]-C-SNAT4 radiotracer uptake post injection.

Study Design

Conditions

Cancer

Intervention

18F-C-SNAT4, Positron emission tomography (PET)/Computed tomography (CT) Scan

Location

Stanford University
Stanford
California
United States
94304

Status

Not yet recruiting

Source

Stanford University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-07-18T10:31:17-0400

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Medical and Biotech [MESH] Definitions

An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.

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Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.

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