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The present study is based on the hypothesis, that recurrent pregnancy loss (RPL) is associated with abnormal mannose binding lectin (MBL) plasma level. Secondarily, MBL plasma level may affect the perinatal outcome in the first pregnancy following RPL. Thus, the present study aim to examine whether MBL should be a biomarker for women at risk for RPL and, secondarily, perinatal complications, and consequently help identify fragile women who need intensified perinatal care.
Recurrent pregnancy loss (RPL), defined as 3 or more consecutive pregnancy losses before 22 weeks of gestation, is a multifactorial disorder, affecting 1-3% of all couples aiming to have a child. The cause of RPL remain unknown in up to 50% of cases. Some of these cases may be affected by an aberrant immune system. Low levels of mannose binding lectin (MBL) in plasma have been associated with RPL, chorioamnionitis, and low birth weight, while high MBL levels have been associated with pro-inflammatory properties resulting in preterm labor and preeclampsia.
Previous studies of MBL have proposed that high and low plasma levels, both may possess a negative effect by priming or promoting an aggressive immune response resulting in autoimmunity and tissue damage.
This study is a single center case-control study and historical cohort study, that aims to investigate wether high and/or low MBL plasma levels are associated with RPL (primary outcome) and whether it affects perinatal outcome in the first pregnancy following the RPL and pregnancy outcome from before RPL in women with secondary RPL (secondary outcome). Thus, if such association exists, MBL could become an biomarker for the early identification of women with need for intensified perinatal care.
The study sample consists of Danish women admitted to the Centre for Recurrent Pregnancy Loss of Western Denmark and the control group consists of Danish female blood donors of fertile age with unknown reproductive history. The study sample and control group target about 350 women, each.
Female patients in the study sample will have a blood sample taken at their first meeting in the Recurrent Miscarriage Center before they become pregnant, and they will be followed until delivery of the first child after RPL, if pregnancy after RPL is achieved. Data of perinatal outcome will be collected from hospital records.
Investigate the association of MBL plasma levels with RPL and perinatal outcome before and after RPL.
Aalborg University Hospital
Aalborg University Hospital
Published on BioPortfolio: 2019-07-18T10:31:19-0400
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