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VMAT Concurrent Cisplatin Plus Nab-paclitaxel for Local Advanced Cervical Cancer

2019-07-18 10:31:23 | BioPortfolio

Summary

This is a single arm, open-lable Phase I clinical trial. Eligible patients will have Histologically proven stage IB2-IVA cervical cancer. We hypothesize that Nab-paclitaxel in combination with cisplatin and radiotherapy may have anti-tumor activity in patients with cervical cancer. Nab-paclitaxel has not previously been combined with conventional RT-CT to treat cervical cancer.

Description

During the phase I study, patients will receive radiation therapy to pelvis (50.4 Gy in 28fractions), and followed by HDR intracavitary (30Gy in 5 fractions) brachytherapy. Concurrent chemotherapy was administered with weekly cisplatin (40 mg/m^2) and an escalating dose of weekly Nab-paclitaxel starting at 10 mg/m^2 up to 70 mg/m^2. Chemotherapy agents were administered in escalating doses to cohorts of three patients at each dose level.

Study Design

Conditions

Cervical Cancer

Intervention

Drug: Cisplatin; nab-paclitaxel

Status

Not yet recruiting

Source

Peking University Third Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-07-18T10:31:23-0400

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