No Reflow Phenomenon Incidence and Predictors

2019-07-17 10:04:58 | BioPortfolio


Background No reflow phenomenon is described in up to 65% of patients undergoing primary percutaneous coronary intervention for ST elevation myocardial infarction (STEMI). It is known to be associated with worse outcomes but predictors of no reflow are not clearly described.

Objectives A single centre case-control observational study of patients presenting with acute myocardial infarction appropriate for PPCI comparing baseline clinical, biochemical and angiographic characteristics between patients with no reflow phenomenon and those without. Aiming to establish incidence for the UK population.

Secondary outcomes will be to gain further insight into those presenting with STEMI for PPCI and develop a risk model to guide management and clinical outcomes of patients to 30days.

Methods This study will prospectively recruit all consecutive patients attending a single centre for primary percutaneous coronary intervention for STEMI. Angiographic assessment of the recanalised epicardial vessel will be used to diagnose no reflow (reduced TIMI flow or blush grade). Baseline demographic, angiographic and biochemical characteristics and outcomes at 30days for reflow and no reflow cohorts will be statistically assessed and compared with logistic regression.

Study Design


No Reflow Phenomenon


No intervention as observational study


Castle Hill Hospital (Hull and east Yorkshire Hospitals NHS Trust)
East Yorkshire
United Kingdom
HU16 5JQ




Hull and East Yorkshire Hospitals NHS Trust

Results (where available)

View Results


Published on BioPortfolio: 2019-07-17T10:04:58-0400

Clinical Trials [721 Associated Clinical Trials listed on BioPortfolio]

Intracoronary Tirofiban on No-Reflow Phenomena

The goal of this study was to evaluate the acute effect of intracoronary administration of tirofiban on no-reflow phenomenon in patients with STEMI and occurrence of no-reflow phenomenon u...

NGAL and Its Association With the No-reflow Phenomenon in ST-elevation Myocardial Infarction

The aim of this study is to investigate the association between NGAL plasma levels in ST-elevation myocardial infarction and the no-reflow phenomenon, adverse events during hospitalization...

Prevention of Coronary Slow Flow or No-Reflow During EPCI in Patients With Acute STEMI

Elective percutaneous coronary intervention (EPCI) is the common treatment of ST segment elevation myocardial infarction (STEMI).Slow flow / no-reflow phenomenon following EPCI in STEMI pa...

Prevention of Coronary Slow Flow or No-Reflow During PPCI in Patients With Acute STEMI

Primary percutaneous coronary intervention (PPCI) is the gold standard of treatment of ST segment elevation myocardial infarction (STEMI).Slow flow / no-reflow phenomenon following PPCI in...

Effects of Ticagrelor on No-reflow in Patients With Acute ST-segment Elevation Myocardial Infarction

The 'no-reflow' phenomenon after a percutaneous coronary intervention (PCI) in patients with acute ST-segment elevation myocardial infarction (STEMI) is a strong predictor of both short- a...

PubMed Articles [14694 Associated PubMed Articles listed on BioPortfolio]

Predictors and outcomes of no-reflow phenomenon in patients with acute ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention.

The aim of this study is to identify the predictors of angiographic no-reflow development in patients who underwent primary percutaneous coronary intervention and to investigate the long-term (median ...

Improved adherence in older patients with hypertension: An observational study of a community-based intervention.

This study sought to assess the effect of a community-based intervention influencing adherence status at baseline, 1, 3 and 6 months, and to evaluate the impact that a community-based intervention an...

Platelet dysfunction after out of hospital cardiac arrest. Results from POHCAR: a prospective observational, cohort study.

Coagulation and platelet function following out of hospital cardiac arrest (OHCA) at admission to a UK cardiology centre were investigated prospectively in this observational feasibility study, and co...

Change in Mental Health Stigma After a Brief Intervention Among Internally Displaced Persons in Central Sudan.

Stigmatizing attitudes towards people with mental illness is a worldwide phenomenon, This Longitudinal study aimed to determine the level of stigma, among the internal displaced persons in central Sud...

Monitoring of drug treatment and psychosocial intervention with SPECT in Alzheimer patients Implications for neurologically appropriate psychosocial interventions. An observational study. The Osaki-Tajiri Project.

We previously examined cerebral blood flow (CBF) with single-photon emission computed tomography (SPECT) in Alzheimer's disease (AD) with reference to drug treatment (donepezil) and psychosocial inter...

Medical and Biotech [MESH] Definitions

Markedly reduced or absent REPERFUSION in an infarct zone following the removal of an obstruction or constriction of an artery.

A work that reports on the results of a clinical study in which participants may receive diagnostic, therapeutic, or other types of interventions, but the investigator does not assign participants to specific interventions (as in an interventional study).

A study in which observations are made before and after an intervention, both in a group that receives the intervention and in a control group that does not.

A study that uses observations at multiple time points before and after an intervention (the "interruption"), in an attempt to detect whether the intervention has had an effect significantly greater than any underlying trend over time.

A study that compares a group of participants receiving an intervention with a similar group from the past who did not.

More From BioPortfolio on "No Reflow Phenomenon Incidence and Predictors"

Quick Search

Searches Linking to this Trial