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Obese people have an altered immune responsiveness. We investigate whether this influences immune responses to booster vaccinations (in this study the Booster vaccination is FSME Immun) and if a modification of vaccination schedules is needed.
Obese adults (BMI >30) >18 - 60 years are compared with adults with normal weight (BMI <25) concerning TBE-NT- antibody- Titer, TBE- antibody -Titercourse and cellular immunity, metabolic parameters and sexual hormones will be tested and compared as well.
Obese people have an altered immune responsiveness. We investigate whether this influences immune responses to booster vaccinations (Booster: TBE-Vaccine: FSME Immun) and if a modification of vaccination schedules is needed.
We will test and compare the humoral and cellulare immune response of obese persons (BMI>30) and persons with normal weight (BMI<25) before and after a Booster with FSME Immun (TBE vaccine) Studies have shown that obesity has a direct effect on the immune system and leads to immunosuppression, which leads to a susceptibility to infection.
The aim of this study is to clarify if a modification of vaccination schedules or a change of booster intervals is necessary for obese people.
Furthermore this study will increase our understanding of the influence of obesity on different components of the immune system, as well as on the quality and quantity of the immune responses.
At Screening (visit 1) demographic Parameter (age, gender, weight, BMI, waist/hip-ratio) will be recorded, metabolic parameters (Cholesterol, Triglycerides, HDL, LDL, Apolipoproteine, Lp(a), Glucose, Fructosamin, Leptin, Leptinreceptor on T and B-Zellen (PCR), Insulin, highsensitive CRP) and Sexual hormones (Testosterone, Estrogen, Progesteron, FSH, LH) will be tested and at visit 3 some metabolic parameters Cholesterol, Triglycerides, HDL, Glucose, Fructosamin, Insulin und highsensitive CRP will be tested again.
All parameters will be compared and correlated with humoral and cellular immune response.
Immunglobuline: IgG, IgE, IgD, IgM, IgA will be tested at visit 1-4.
TBE antibody titer (NT) will be tested and titer course will be evaluated at visit 1-5
After visit 1 und 2 Isolation of PBMC (Peripheral Blood Mononuclear Cells) with Ficoll gradient
Following tests will be performed:
1. Cytokin concentration will be measured after restimulating the PBMCs with TBE-Antigen. Duration of stimulaton: 48h; Detection with Luminex platform/ELISA: IL-2, IFNgamma, IL-10, TNF-alpha und IL-6
2. flow cytometry: Characterization of different Lymphocyt-Subpopulations with Antibody-Panels (CD surface marker : CD19, CD3, IgD, IgM, IgG, IgA, CD10, CD27, CD127, CCR4, CD8, CD4, CD28, CD31, CD38, CCR7, CD45RA, CD25, CD24, CD38 und FOXP3).
Serious Adverse and adverse events will be recorded at all visits
All participants will be tested again at V5, performing TBE-Neutralisation-Test, three years after the booster vaccination for analysis of longterm immunogenicity. Demographic parameters will be recorded again.
Participants who are not protected against TBE for another year, three years after the booster vaccination at V5 (NT <20), are getting a booster vaccination for free.
V1 day 0, V2 day 7+3,V3 1 month +/-7 days, V4 6 months +/-14d V5 36 months+/- 1 month V6 only if TBE NT<20
Tick Borne Encephalitis
Medical University Vienna, Institute of Specific Prophylaxis and Tropical Medicine
Active, not recruiting
Medical University of Vienna
Published on BioPortfolio: 2019-07-17T10:04:59-0400
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The causative agent of tick-borne encephalitis (a neurotropic RNA virus from the Flavivirus genus) can cause both severe paralytic forms of the disease (meningoencephalitis, etc.) and milder nonparaly...
Tick-borne encephalitis virus (TBEV) is most commonly transmitted to humans via the bite of an infected tick. Alimentary infection through the consumption of TBEV-contaminated dairy products is also w...
The aim of our study is to evaluate immune response after receiving the primary vaccination against tick-borne encephalitis (TBE), and to establish a link between seropositivity and selected factors i...
The aim of this seroepidemiological study was to determine the current prevalence of antibodies against tick-borne encephalitis virus (TBEV) in the representative group of Slovak population with inclu...
Tick-borne encephalitis (TBE) is an illness caused by tick-borne encephalitis virus (TBEV) infection which is often limited to a febrile illness, but may lead to very aggressive downstream neurologica...
Encephalitis caused by neurotropic viruses that are transmitted via the bite of TICKS. In Europe, the diseases are caused by ENCEPHALITIS VIRUSES, TICK-BORNE, which give rise to Russian spring-summer encephalitis, central European encephalitis, louping ill encephalitis, and related disorders. Powassan encephalitis occurs in North America and Russia and is caused by the Powassan virus. ASEPTIC MENINGITIS and rarely encephalitis may complicate COLORADO TICK FEVER which is endemic to mountainous regions of the western United States. (From Joynt, Clinical Neurology, 1996, Ch26, pp14-5)
The largest genus of TICKS in the family IXODIDAE, containing over 200 species. Many infest humans and other mammals and several are vectors of diseases such as LYME DISEASE, tick-borne encephalitis (ENCEPHALITIS, TICK-BORNE), and KYASANUR FOREST DISEASE.
A subgroup of the genus FLAVIVIRUS that causes encephalitis and hemorrhagic fevers and is found in eastern and western Europe and the former Soviet Union. It is transmitted by TICKS and there is an associated milk-borne transmission from viremic cattle, goats, and sheep.
Chemical, biological, or medical measures designed to prevent the spread of ticks or the concomitant infestations which result in tick-borne diseases. It includes the veterinary as well as the public health aspects of tick and mite control.
Bacterial, viral, or parasitic diseases transmitted to humans and animals by the bite of infected ticks. The families Ixodidae and Argasidae contain many bloodsucking species that are important pests of man and domestic birds and mammals and probably exceed all other arthropods in the number and variety of disease agents they transmit. Many of the tick-borne diseases are zoonotic.
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