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Targeting Hippocampal Hyperactivity With Real-time Functional MRI Based Neurofeedback in Elderly Individuals With and Without Memory Problems

2019-07-19 10:43:31 | BioPortfolio

Summary

Increased activity in the hippocampus (i.e. hyperactivity) during a memory task in the magnetic resonance (MR) scanner was found both in healthy elderly participants as well as in patients with mild cognitive impairment (MCI, a prodromal of Alzheimer's disease). Additionally, individuals with increased hippocampal activity showed elevated amyloid-ß load over time, accompanied with an increased progression rate to Alzheimer's disease. Reducing hippocampal hyperactivity with pharmacological treatment improved memory functions in patients with MCI. The investigators will apply real-time fMRI based neurofeedback to downregulate hippocampal activity and thereby test if this is beneficial for memory functions.

Description

Alzheimer`s disease (AD) is an insidious and progressive neurodegenerative disease accompanied by extracellular deposits of beta-amyloids (⁠aβ) and the increase of cognitive dysfunctions. Several functional magnet resonance imaging (fMRI) studies in the prodromal stage of AD have found increased hippocampal activity during a memory task to be predictive of memory worsening and disease progression. In this study the investigators are aiming to reduce hippocampal hyperactivity with real-time functional magnet resonance imaging (rtfMRI) based neurofeedback.

This study will use a multicenter, placebo-controlled, randomized, double-blinded parallel group design. Patients with mild cognitive impairment (MCI) and healthy participants will be assigned to receive rtfMRI from either the hippocampus (experimental group, N=40) or from another brain area (alternate region of interest (ROI) feedback group, N=40). All participants will be instructed to downregulate their hippocampal activity to a target level.

Study Design

Conditions

Mild Cognitive Impairment

Intervention

real-time fMRI based neurofeedback from the hippocampus, real-time fMRI based neurofeedback from another brain area

Location

SITEM (Swiss Institute for Translational and Entrepreneurial Medicine)
Bern
Switzerland
3010

Status

Not yet recruiting

Source

University of Bern

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-07-19T10:43:31-0400

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