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Comparison of High-dose Rosuvastatin Versus Low-dose Rosuvastatin Plus Ezetimibe on Carotid Plaque Inflammation in Patients With Acute Coronary Syndrome

2019-08-19 19:46:43 | BioPortfolio

Summary

Combination therapy of ezetimibe with a low-dose statin is occasionally used to avoid statin-related side effects in clinical practice among patients with atherosclerotic cardiovascular disease. This approach is equivalent to high-dose statin therapy to decrease LDL cholesterol level by >50%, allowing such patients to achieve LDL cholesterol target. However, it remains uncertain whether combination therapy with ezetimibe and low-dose statin verse high-dose statin monotherapy similarily suppress atherosclerotic plaque inflammation. This study is to compare high-dose rosuvastatin versus low-dose rosuvastatin plus ezetimibe on carotid plaque inflammation in patients with acute coronary syndrome using 18F-fluorodeoxyglucose (18FDG) positron emission tomography (PET) imaging.

Study Design

Conditions

Acute Coronary Syndrome

Intervention

high-dose rosuvastatin, low-dose rosuvastatin plus ezetimibe

Location

Asan Medical Center
Seoul
Korea, Republic of

Status

Completed

Source

Yuhan Corporation

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-08-19T19:46:43-0400

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