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A Single Dose FMT Infusion as an Adjunct to Keytruda for Metastatic Mesothelioma

2019-08-17 19:30:48 | BioPortfolio

Summary

The investigators propose to ensure a favorable gut microbiome by fecal microbiota transplant to enhance the efficacy Keytruda in a single-patient.

Description

Studies have shown that a favorable microbiome can be the difference between response and non-response of certain cancer treatments such as PD-1 blockade inhibitors. As such the investigators propose to ensure a favorable microbiome in this patient by fecal microbiota transplant to enhance the efficacy of such a drug, Keytruda.

Study Design

Conditions

Mesothelioma

Intervention

Fecal Microbiota Transplant

Location

ProgenaBiome
Ventura
California
United States
93003

Status

No longer available

Source

ProgenaBiome

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-08-17T19:30:48-0400

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Medical and Biotech [MESH] Definitions

Transfer of GASTROINTESTINAL MICROBIOTA from one individual to another by infusion of donor FECES to the upper or lower GASTROINTESTINAL TRACT of the recipient.

A peritoneal mesothelioma affecting mainly young females and producing cysts of variable size and number lined by a single layer of benign mesothelial cells. The disease follows a benign course and is compatible with a normal life expectancy, requiring occasionally partial excision or decompression for relief of pain or other symptoms. Malignant potential is exceptional. (From Holland et al., Cancer Medicine, 3d ed, p1345)

An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.

Providers of tissues for transplant to non-related individuals.

Transplant comprised of an individual's own tissue, transferred from one part of the body to another.

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