Accelerated Theta Burst Stimulation for Inpatients With Bipolar Disorder

2019-08-21 20:05:52 | BioPortfolio


This study evaluates the efficacy of an accelerated schedule of theta-burst stimulation for bipolar disorder. In this open-label study, all participants will receive accelerated theta-burst stimulation.


Repetitive transcranial magnetic stimulation (rTMS) is an established technology as therapy for treatment-resistant depression. The approved method for treatment is 10Hz stimulation for 40 minutes over the left dorsolateral prefrontal cortex (L-DLPFC). This methodology has been very successful in real-world situations. The limitations of this approach include the duration of the treatment (approximately 40 minutes per treatment session over 4-6 weeks). Recently, researchers have modified the treatment parameters to reduce treatment times with some preliminary success. In a recent study, an accelerated paradigm showed a significant antidepressant effect (90% remission rate) in individuals with treatment-resistant depression (TRD), in only 5 days . Additionally, 5 participants from this study carried a bipolar diagnosis and responded equally as well, with no adverse events experienced or manic/hypomanic conversion observed during the treatment series. This study intends to further modify the parameters to create a more rapid form of this treatment for bipolar disorder and look at the change in clinical measures and neuroimaging biomarkers.

Study Design


Bipolar Disorder, Manic


Accelerated intermittent theta-burst stimulation over right DLPFC


Stanford Hospital
Palo Alto
United States


Not yet recruiting


Stanford University

Results (where available)

View Results


Published on BioPortfolio: 2019-08-21T20:05:52-0400

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Medical and Biotech [MESH] Definitions

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