Topics

Use of DTT to Define Facial Nerve Position in Vestibular Schwannomas

2019-08-18 20:09:22 | BioPortfolio

Summary

Vestibular schwannomas (VS) arise from the vestibulocochlear (hearing and balance) nerve, located at the base of the brain. Although benign, VS can enlarge over time, resulting in debilitating symptoms; therefore, surgical removal is frequently offered. One significant risk of surgery is inadvertent injury to the facial nerve, which lies adjacent to the vestibulocochlear nerve. Currently, the nerve's course is only revealed during surgical dissection and injury can cause permanent facial weakness. It would therefore be useful for the surgeon to know the course of the nerve before operating. To this end, a new MRI technique known as probabilistic diffusion tensor tractography (DTT) has shown potential in revealing the course of the facial nerve pre-operatively. However, its clinical reliability remains uncertain.

This study aims to investigate the reliability of DTT in identifying the course of the facial nerve preoperatively in patients undergoing surgery for VS.

The future benefit would be to enable surgeons to operate with more confidence and potentially reduce the chance of nerve injury.

The study will recruit adult patients due to have surgery for VS. The only change to the participants' clinical pathways will be the addition of a DTT sequence to their pre-operative MRI scans (increasing scanning time by approximately 10 minutes).

Study Design

Conditions

Vestibular Schwannoma

Intervention

Probabilistic diffusion tensor tractography

Location

King's College Hospital NHS Foundation Trust
London
United Kingdom
SE5 9RS

Status

Recruiting

Source

King's College Hospital NHS Trust

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-08-18T20:09:22-0400

Clinical Trials [419 Associated Clinical Trials listed on BioPortfolio]

Role of Psychiatric Profile in Prehabituated Patients After Vestibular Schwannoma Surgery

The aim of this study is to assess effect of psychiatric profile on visual sensitivity and overall health status in patients who underwent surgery for vestibular schwannoma and were prehab...

Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma

Surgical removal of vestibular schwannoma causes acute vestibular symptoms, including postoperative vertigo and oscilopsia due to nystagmus. In general, the dominant symptom postoperativel...

Vestibular Outcomes in Vestibular Schwannoma

Previous studies have shown that vertigo is the symptoms that mostly affect quality of life in patients with vestibular schwannoma. There is still limited knowledge as to why some patients...

Validation of Edema-invariant Multi-shell High Angular Resolution Diffusion Imaging (msHARDI)-Based Tractography With Intra-operative Cortical Stimulation

Currently, standard-of-care tractography is based on information obtained from diffusion tensor imaging (DTI). DTI is a diffusion magnetic resonance imaging (dMRI) technique that is routin...

Vestibular Evaluation After Vestibular Schwannoma Treatment

Vestibular schwannoma is a benign tumor located on the vestibular nerve. Patient could present dizziness symptoms cause to the tumor, and at least after the treatment by gamaknife radiosur...

PubMed Articles [2421 Associated PubMed Articles listed on BioPortfolio]

Preoperative prediction of facial nerve in patients with Vestibular Schwannomas: the role of diffusion tensor imaging. A systematic review.

In vestibular schwannoma surgery the preservation of facial and cochlear nerves is of paramount concern with regard to their impact on the quality of life. The rate of nerve function preservation rais...

Structural and functional connectivity of ascending reticular activating system in a patient with impaired consciousness after a cardiac arrest: A case report.

Diffusion tensor imaging (DTI), diffusion tensor tractography (DTT), as well as resting-state-functional magnetic resonance imaging (rsfMRI) are promising methods for assessing patients with disorders...

Diffusion tensor imaging and fiber tractography reveal significant micro-structural changes of cervical nerve roots in cervical spondylotic radiculopathy patients.

We sought to delineate the fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of cervical spondylotic radiculopathy patients by diffusion tensor imaging (DTI) and fiber bundle ...

Vestibular schwannoma extending into the tympanic cavity and jugular fossa by invasion of the petrous bone.

Vestibular schwannomas usually originate in the internal acoustic meatus, and gradually extends into the cerebellopontine cistern. Invasive growth into the petrous bone is extremely rare. We describe ...

Correlation of Pre-Operative Cranial Nerves Diffusion Tensor Tractography with Intra-operative findings in Surgery of Cerebellopontine Angle Tumors.

Imaging to visualize nerves around tumors preoperatively may help the surgeon to plan surgery and excise the tumor with preservation or improvement in the quality of life. In this prospective study, t...

Medical and Biotech [MESH] Definitions

The use of diffusion ANISOTROPY data from diffusion magnetic resonance imaging results to construct images based on the direction of the faster diffusing molecules.

A benign SCHWANNOMA of the eighth cranial nerve (VESTIBULOCOCHLEAR NERVE), mostly arising from the vestibular branch (VESTIBULAR NERVE) during the fifth or sixth decade of life. Clinical manifestations include HEARING LOSS; HEADACHE; VERTIGO; TINNITUS; and FACIAL PAIN. Bilateral acoustic neuromas are associated with NEUROFIBROMATOSIS 2. (From Adams et al., Principles of Neurology, 6th ed, p673)

The vestibular part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The vestibular nerve fibers arise from neurons of Scarpa's ganglion and project peripherally to vestibular hair cells and centrally to the VESTIBULAR NUCLEI of the BRAIN STEM. These fibers mediate the sense of balance and head position.

A diagnostic technique that incorporates the measurement of molecular diffusion (such as water or metabolites) for tissue assessment by MRI. The degree of molecular movement can be measured by changes of apparent diffusion coefficient (ADC) with time, as reflected by tissue microstructure. Diffusion MRI has been used to study BRAIN ISCHEMIA and tumor response to treatment.

Vestibular nucleus lying immediately superior to the inferior vestibular nucleus and composed of large multipolar nerve cells. Its upper end becomes continuous with the superior vestibular nucleus. (From Dorland, 28th ed)

More From BioPortfolio on "Use of DTT to Define Facial Nerve Position in Vestibular Schwannomas"

Quick Search

Relevant Topics

Hearing
Hearing, auditory perception, or audition is the ability to perceive sound by detecting vibrations, changes in the pressure of the surrounding medium through time, through an organ such as the ear. Sound may be heard through solid, liquid, or gaseous mat...

Surgical treatments
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...

Radiology
Radiology is the branch of medicine that studies imaging of the body; X-ray (basic, angiography, barium swallows), ultrasound, MRI, CT and PET. These imaging techniques can be used to diagnose, but also to treat a range of conditions, by allowing visuali...


Searches Linking to this Trial