Neurobiological Mechanisms of Chess as an Add-On Treatment Against AUD

2019-08-20 20:17:12 | BioPortfolio


Neurobiological and neuropsychological approaches to investigate the potential mechanism of action of chess as an add-on therapy (chess based - cognitive remediation treatment, CB-CRT) to reduce cognitive deficits in individuals with alcohol use disorder (AUD).


The study aims to investigate the potential mechanism of action of chess as a "chess based - cognitive remediation treatment, CB-CRT" to reduce cognitive deficits in individuals with alcohol use disorder (AUD) seeking treatment using neurobiological and neuropsychological approaches. Furthermore, we will assess whether this chess intervention has a generalized positive effect on short-term abstinence. Interestingly, the functional domains and associated underlying neuronal networks observed to be affected in individuals with AUD overlap significantly with those that could be strengthened by chess-based cognitive training or formal chess. Specifically, strengthening of cortical control regions (dorsolateral prefrontal cortex, DLPFC) and brain areas relevant for decision-making (orbitofrontal cortex, OFC) could prevent future relapse. Therefore, chess as an add-on therapy to complement other standard treatments of AUD could lead to improved therapeutic outcomes.

Study Design


Alcohol Use Disorder


Standard therapy for AUD plus Chess-based cognitive treatment, Standard therapy for AUD


Not yet recruiting


Central Institute of Mental Health, Mannheim

Results (where available)

View Results


Published on BioPortfolio: 2019-08-20T20:17:12-0400

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