Antibodies in Repeated Influenza Vaccination (ARIVA) Study

2019-08-25 21:28:56 | BioPortfolio


Viruses with high mutation rates, such influenza or HIV, pose a major challenge for vaccine design. The current influenza vaccination strategy of yearly vaccination with adapted strains aims to maximally diversify the antibody immune response to prevent viral escape. There is, however, growing evidence, that repeated vaccination with very similar viral proteins might limit, instead of broaden, diversification and thereby reduce vaccine efficacy.

The ARIVA Study prospectively studies the immunological impact of repeated influenza vaccination on viral variant recognition and antibody responses in healthy subjects cross-sectionally and over three consecutive vaccination seasons.

Study Design


Vaccine Response Impaired


Influenza Vaccination


University Hospital Basel


Enrolling by invitation


University Hospital, Basel, Switzerland

Results (where available)

View Results


Published on BioPortfolio: 2019-08-25T21:28:56-0400

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