Topics

Antibodies in Repeated Influenza Vaccination (ARIVA) Study

2019-08-25 21:28:56 | BioPortfolio

Summary

Viruses with high mutation rates, such influenza or HIV, pose a major challenge for vaccine design. The current influenza vaccination strategy of yearly vaccination with adapted strains aims to maximally diversify the antibody immune response to prevent viral escape. There is, however, growing evidence, that repeated vaccination with very similar viral proteins might limit, instead of broaden, diversification and thereby reduce vaccine efficacy.

The ARIVA Study prospectively studies the immunological impact of repeated influenza vaccination on viral variant recognition and antibody responses in healthy subjects cross-sectionally and over three consecutive vaccination seasons.

Study Design

Conditions

Vaccine Response Impaired

Intervention

Influenza Vaccination

Location

University Hospital Basel
Basel
Switzerland

Status

Enrolling by invitation

Source

University Hospital, Basel, Switzerland

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-08-25T21:28:56-0400

Clinical Trials [4014 Associated Clinical Trials listed on BioPortfolio]

Immune Response to Influenza Vaccine in ESRD Patients

On-line hemodiafiltration (HDF) clears more azotaemic toxins compared to high-flux hemodialysis (HD). The response to vaccination is impaired in dialysis patients. We aimed to study the im...

Reducing the Burden of Influenza After Solid-Organ Transplantation

Influenza is associated with significant morbidity and mortality in solid-organ transplant (SOT) recipients and it is mainly prevented by seasonal influenza vaccination. Unfortunately, the...

Immune Response and Risk of Side Effects After Influenza Vaccination in Athletes

Seasonal influenza vaccination was used to assess whether induction of immunity as well as the rate of side effects is influenced by the timing of the last training session before vaccinat...

Study of Immune Responses to Influenza Vaccination

Better understanding of the immune responses to influenza vaccination is needed in order to understand situations of poor vaccine response. Adults will receive influenza vaccination and th...

Study of Immune Response in Adults and Elderly Subjects Vaccinated With Inactivated Influenza Vaccines

To further characterize the immune responses induced after an influenza vaccination performed either via the ID or the IM routes in two clearly distinct populations. Objectives: ...

PubMed Articles [11580 Associated PubMed Articles listed on BioPortfolio]

Pre-existing subtype immunodominance shapes memory B cell recall response to influenza vaccination.

Influenza is a highly contagious viral pathogen with more than 200,000 cases reported in the U.S. during the 2017-2018 season. Annual vaccination is recommended by the World Health Organization with t...

Fc functional antibody responses to adjuvanted versus unadjuvanted seasonal influenza vaccination in community-dwelling older adults.

Seasonal influenza vaccination with a standard trivalent influenza vaccine (TIV) induces a modest, and cross-reactive, Fc functional antibody response in older adults. Recent improvements to influenza...

Seasonal influenza vaccination among older adults in Jordan: prevalence, knowledge, and attitudes.

: The current study aimed to evaluate the prevalence, level of knowledge and attitudes to seasonal influenza vaccination among older adults in Jordan.: This was a cross-sectional study in which a clos...

Relationship of pneumococcal and influenza vaccination frequency with health literacy in the rural population in Turkey.

Vaccines have been shown to prevent illness, disability and death from vaccine-preventable diseases. The purpose of our study was to analyze the influenza and pneumococcal vaccination status of patien...

Interplay between cost and effectiveness in influenza vaccine uptake: a vaccination game approach.

Pre-emptive vaccination is regarded as one of the most protective measures to control influenza outbreak. There are mainly two types of influenza viruses-influenza A and B with several subtypes-that a...

Medical and Biotech [MESH] Definitions

Vaccines used to prevent infection by viruses in the family ORTHOMYXOVIRIDAE. It includes both killed or attenuated vaccines. The composition of the vaccines is changed each year in response to antigenic shifts and changes in prevalence of influenza virus strains. The vaccine is usually bivalent or trivalent, containing one or two INFLUENZAVIRUS A strains and one INFLUENZAVIRUS B strain.

The relationship between an elicited ADAPTIVE IMMUNE RESPONSE and the dose of the vaccine administered.

Administration of a vaccine to large populations in order to elicit IMMUNITY.

The cutaneous and occasional systemic reactions associated with vaccination using smallpox (variola) vaccine.

A live VACCINIA VIRUS vaccine of calf lymph or chick embryo origin, used for immunization against smallpox. It is now recommended only for laboratory workers exposed to smallpox virus. Certain countries continue to vaccinate those in the military service. Complications that result from smallpox vaccination include vaccinia, secondary bacterial infections, and encephalomyelitis. (Dorland, 28th ed)

More From BioPortfolio on "Antibodies in Repeated Influenza Vaccination (ARIVA) Study"

Quick Search

Relevant Topic

Influenza
Influenza or 'flu' is a respiratory illness associated with infection by influenza virus. Symptoms frequently include headache, fever, cough, sore throat, aching muscles and joints. There is a wide spectrum of severity of illness ranging from min...


Searches Linking to this Trial