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This study is a multicenter, randomized, open-label, parallel, phase IV trial.
The study is planned to include 272 patients with a clinical atherosclerotic cardiovascular disease requiring optimal statin therapy.
After enrollment, subjects are randomized into two groups in a 1:1 manner. The combination therapy group will receive a single-pill combination of rosuvastatin 10 mg and ezetimibe 10 mg once daily.
The subjects in the intensive statin group will receive rosuvastatin 20 mg once daily.
Subjects will visit at weeks 12 and 24 to identify medication adherence and clinical side effects.
The primary endpoint of this study is a % change of low-density lipoprotein cholesterol at 12 weeks.
Efficacy and safety of combination therapy of moderate-intensity statin and ezetimibe compared to high-intensity statin
Seoul National University Bundang Hospital
Korea, Republic of
Active, not recruiting
Seoul National University Bundang Hospital
Published on BioPortfolio: 2019-09-12T02:34:42-0400
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A pharmaceutical preparation of ezetimibe and simvastatin that is used in the treatment of HYPERCHOLESTEROLEMIA and HYPERLIPIDEMIAS.
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Usual level of physical activity that is less than 30 minutes of moderate-intensity activity on most days of the week.
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property.
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