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Tetracycline to Limit the Innate Immune Response in Acute Respiratory Distress Syndrome

2019-09-11 01:53:29 | BioPortfolio

Summary

The acute respiratory distress syndrome (ARDS) is a severe form of respiratory failure with a mortality rate of approximately 40%. Despite advances in its supportive treatment such as lung protective ventilation or restrictive fluid management, no effective pharmacotherapy exists to treat ARDS. Emerging preclinical data indicates that excessive activation of the inflammasome-Caspase 1 pathway plays a key role in the development of ARDS. Tetracycline has anti-inflammatory properties via inhibiting inflammasome-caspase-1 activation. Since not much is known about the activation of the inflammasome in clinical ARDS, the purpose of this study is i) to investigate the the inflammasome-caspase-1 activation in clinical ARDS and ii) inhibit the innate immune response of alveolar leucocytes obtained by tetracycline from patients with ARDS

Study Design

Conditions

Adult Respiratory Distress Syndrome

Intervention

Sampling of Blood and bronchoalveolar lavage

Location

University Hospital Bonn
Bonn
Germany
53127

Status

Recruiting

Source

University of Bonn

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-11T01:53:29-0400

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Medical and Biotech [MESH] Definitions

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