Restoring Molecular Circadian Rhythm

2019-09-17 02:47:36 | BioPortfolio


The goal is to address the mechanisms that account for alteration of circadian rhythms with age. As the blood of aged individuals can produce this alteration, we propose to use such blood samples to "age" circadian rhythms in cultured cells. We will verify aged blood-dependent alteration of rhythms and then conduct molecular screens to reverse this decline. If we identify specific genes that can restore molecular circadian rhythm in vitro, we will explore these in animal models (Drosophila, mouse).

Study Design


Healthy Young


Observational study without intervention


University of Pennsylvania School of Medicine
United States




University of Pennsylvania

Results (where available)

View Results


Published on BioPortfolio: 2019-09-17T02:47:36-0400

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