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No substantial clinical trials of Cannabidiol (CBD) in Social Anxiety Disorder (SAD) have yet been conducted. This randomized doubleblind, placebo-controlled trial of CBD in adults with SAD will evaluate the efficacy, tolerability and safety of CBD oil (CHI-902) in SAD. In addition, the effects of treatment with CHI-902 on the Endocannabinoid System (ECS) will be assessed by evaluating peripheral endocannabinoids (Arachidonoylethanolamide/Anandamide (AEA) and 2-Arachidonoyl glycerol (2-AG)) before and after treatment.
This study will evaluate efficacy, therapeutic effects, tolerability and safety of CBD oil in adults with SAD through a randomized placebo-controlled study design and will evaluate effects of CHI-902 on peripheral endocannabinoids (AEA and 2-AG). This study will be the first randomized, double-blind placebo-controlled trial conducted with CHI-902 in adults with SAD.
The study is designed to:
- Evaluate the efficacy of CHI-902 versus placebo in adults with SAD.
- Evaluate the tolerability and safety versus placebo of CHI-902 in adults with SAD.
- Explore the effects of CHI-902 versus placebo on different biomarkers in subjects with SAD.
Social Anxiety Disorder
MacAnxiety Research Center, McMaster University
Not yet recruiting
Canopy Health Innovations
Published on BioPortfolio: 2019-09-17T02:47:38-0400
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Anxiety disorder characterized by the persistent and irrational fear, anxiety, or avoidance of social or performance situations.
A personality disorder manifested by a profound defect in the ability to form social relationships, no desire for social involvement, and an indifference to praise or criticism.
A personality disorder in which there are oddities of thought (magical thinking, paranoid ideation, suspiciousness), perception (illusions, depersonalization), speech (digressive, vague, overelaborate), and behavior (inappropriate affect in social interactions, frequently social isolation) that are not severe enough to characterize schizophrenia.
Persistent difficulties in the social uses of verbal and nonverbal communications. (DSM-V)
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