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A Study to Investigate OQL011 on VEGFR Inhibitor-Associated Hand-Foot Skin Reaction in Cancer Patients

2019-09-19 03:56:51 | BioPortfolio

Summary

Hand-Foot Skin Reaction (HFSR) is a common adverse event induced by Vascular Endothelial Growth Receptor Inhibitor (VEGFRi) treatment in cancer patients. The main purpose of this study is to evaluate the safety and efficacy of OQL011 compared to vehicle ointment in treating patients with moderate to severe VEGFRi-associated HFSR. This study will also identify an optimal dosage for Phase III study and explore the pharmacokinetics profile of OQL011 in HFSR patients.

Study Design

Conditions

Hand-Foot Skin Reaction (HFSR)

Intervention

OQL011, Vehicle Ointment

Location

Memorial Sloan-Kettering Cancer Center
New York
New York
United States
10022

Status

Not yet recruiting

Source

OnQuality Pharmaceuticals (USA) LLC

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-19T03:56:51-0400

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PubMed Articles [11430 Associated PubMed Articles listed on BioPortfolio]

Association of Hand-Foot Skin Reaction with Regorafenib Efficacy in the Treatment of Metastatic Colorectal Cancer.

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Risk of hand-foot skin reaction associated with VEGFR-TKIs: a meta-analysis of 57 randomized controlled trials involving 24956 patients.

Multiple randomized controlled trials have assessed hand-foot skin reaction (HFSR) caused by vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs).

Calcipotriol ointment shows comparable efficacy to topical steroids in chronic hand eczema.

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Medical and Biotech [MESH] Definitions

Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.

Skin diseases of the foot, general or unspecified.

Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.

The farthest or outermost projections of the body, such as the HAND and FOOT.

A congenital anomaly of the hand or foot, marked by the presence of supernumerary digits.

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