A Study to Investigate OQL011 on VEGFR Inhibitor-Associated Hand-Foot Skin Reaction in Cancer Patients

2019-09-19 03:56:51 | BioPortfolio


Hand-Foot Skin Reaction (HFSR) is a common adverse event induced by Vascular Endothelial Growth Receptor Inhibitor (VEGFRi) treatment in cancer patients. The main purpose of this study is to evaluate the safety and efficacy of OQL011 compared to vehicle ointment in treating patients with moderate to severe VEGFRi-associated HFSR. This study will also identify an optimal dosage for Phase III study and explore the pharmacokinetics profile of OQL011 in HFSR patients.

Study Design


Hand-Foot Skin Reaction (HFSR)


OQL011, Vehicle Ointment


Memorial Sloan-Kettering Cancer Center
New York
New York
United States


Not yet recruiting


OnQuality Pharmaceuticals (USA) LLC

Results (where available)

View Results


Published on BioPortfolio: 2019-09-19T03:56:51-0400

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Medical and Biotech [MESH] Definitions

Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.

Skin diseases of the foot, general or unspecified.

Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.

The farthest or outermost projections of the body, such as the HAND and FOOT.

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