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Impact of Anti-platelet Drug Exposure on Platelet mRNA Splicing in Healthy Subjects

2019-09-19 03:56:52 | BioPortfolio

Summary

The purpose of this pilot study is to determine how the anti-platelet drug, ticagrelor, impacts platelet mRNA splicing after a single loading dose in 10 healthy participants. These results will be valuable in that they will help inform our analysis of platelet RNA splicing after a thrombotic event.

Description

There is nothing known on how differential splicing in platelets is impacted by of P2Y12 inhibition by anti-platelet agents. Consequently, the focus of this longitudinal pilot study will be to determine the impact of a single ticagrelor loading dose (180 mg), our "model" anti-platelet drug, on platelet RNA splicing in 10 healthy individuals.

It will test the hypothesis that ticagrelor exposure does not significantly alter platelet mRNA splicing. It will involve administering a single loading dose (180 mg) of ticagrelor to healthy volunteers.

Study Design

Conditions

Thrombosis; Artery

Intervention

Ticagrelor Oral Tablet [Brilinta]

Location

The George Washington University School of Medicine and Health Sciences
Washington
District of Columbia
United States
20037

Status

Not yet recruiting

Source

George Washington University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-19T03:56:52-0400

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