StrataXRT® as a Steroid Sparing Device

2019-09-18 03:27:47 | BioPortfolio


The purpose is to determine if StrataXRT can be used as a steroid sparing agent for the treatment of cutaneous reactions related to acute graft versus host disease (GVHD), cutaneous T Cell lymphoma (CTCL) and chemotherapy/immunotherapy treatments than the current standard treatment - topical steroids - in people who are receiving treatment for CTCL, acute GVHD or chemotherapy/immunotherapy for solid/hematologic malignancies. Subjects will have CTCL or GVHD and are being treated with topical steroids, or being treated with chemotherapy/immunotherapy for another condition and have had cutaneous reactions that have warranted initiation of topical steroids.


Topical steroids are the mainstays of treatment for many cutaneous reactions and disorders. Steroids are known to cause many side effects and few effective pharmacologic alternatives exist. Contact dermatitis is observed in 56% of patients with cutaneous T-cell lymphoma (CTCL) being treated with topical mechlorethamine gel. This usually requires chronic treatment with mid-to high-potency steroids. Numerous chemo/immunotherapies are associated with cutaneous reactions including paronychia, hand and foot syndrome, and acneiform rash. Skin toxicity often requires dose reduction of cancer therapies and a variety of skin directed therapies including topical antibiotics and topical steroids. Cutaneous reactions are often the earliest manifestation of acute graft versus host disease. Skin manifestations can be debilitating and treatment usually requires high potency topical steroids. Additional therapies are needed for the treatment of disorders that rely on topical steroids.

Study Design




StrataXRT gel


Columbia University Medical Center, Department of Dermatology
New York
New York
United States




Columbia University

Results (where available)

View Results


Published on BioPortfolio: 2019-09-18T03:27:47-0400

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PubMed Articles [11 Associated PubMed Articles listed on BioPortfolio]

A single-blind, randomised controlled trial of StrataXRT® - A silicone-based film-forming gel dressing for prophylaxis and management of radiation dermatitis in patients with head and neck cancer.

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