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Phase Ia Clinical Trial of Protein Based Pneumococcal Vaccine

2019-09-16 03:26:27 | BioPortfolio

Summary

Infections with Streptococcus pneumoniae often cause serious health problems, especially for infants and the elderly.Failure to cover all polysaccharide types is an even greater problem with adults than with children.

The aim of the study is to preliminary evaluate the safety and immunogenicity of PBPV vaccine compared to placebo,in order to provide a basis for subsequent clinical trial design.

Description

The polysaccharide vaccine protected 60% of elderly adults who were at risk for pneumococcal infection.However, pneumococci are highly diverse with respect to their capsular types , and the polysaccharide-protein conjugate vaccines will not protect against strains of the many capsular types not included in the vaccine.This experimental vaccine was covered 70% of all pneumococcal types, Subjects will receive three doses of PBPV vaccine on day 0,60 and 120 with different contents of 20μg,50μg,100μg each antigen in 18 to 49 years of age.

Study Design

Conditions

Pneumonia

Intervention

Protein based pneumococcal vaccine(Low dose), Protein based pneumococcal vaccine placebo(Low dose), Protein based pneumococcal vaccine(Middle dose), Protein based pneumococcal vaccine placebo(Middle dose), Protein based pneumococcal vaccine(High dose), Pr

Location

Henan Province Center for Disease Control and Prevention
Zhengzhou
Henan
China
450016

Status

Not yet recruiting

Source

CanSino Biologics Inc.

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-16T03:26:27-0400

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Medical and Biotech [MESH] Definitions

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