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Denosumab to Prevent High-Turnover Bone Loss After Bariatric Surgery

2019-09-18 03:27:53 | BioPortfolio

Summary

Bariatric surgery leads to bone loss and increases fracture risk. This study evaluates whether denosumab can prevent the high-turnover bone loss that occurs after Roux-en-Y Gastric Bypass (RYGB) and sleeve gastrectomy (SG) surgery.

Description

Bariatric surgery is a highly effective weight loss treatment, but one of the unintended side effects of these procedures is high-turnover bone loss and metabolic bone disease. Denosumab is a monoclonal antibody to RANKL that acts as a potent inhibitor of bone resorption. The investigators are conducting a randomized placebo-controlled trial to evaluate the ability of denosumab to prevent bone loss after RYGB or SG surgery in older adults.

Study Design

Conditions

Bariatric Surgery Candidate

Intervention

Denosumab, Placebo

Location

University of California, San Francisco
San Francisco
California
United States
94143

Status

Not yet recruiting

Source

Massachusetts General Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-18T03:27:53-0400

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Medical and Biotech [MESH] Definitions

Surgical procedures aimed at producing major WEIGHT REDUCTION in patients with MORBID OBESITY.

Activities related to WEIGHT REDUCTION in patients with OBESITY. Treatment methods include DIET; EXERCISE; BEHAVIOR MODIFICATION; medications; and BARIATRIC SURGERY.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

A humanized monoclonal antibody and an inhibitor of the RANK LIGAND, which regulates OSTEOCLAST differentiation and bone remodeling. It is used as a BONE DENSITY CONSERVATION AGENT in the treatment of OSTEOPOROSIS.

The discipline concerned with WEIGHT REDUCTION in patients with OBESITY.

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