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The Role of microRNA-210 in Regulating Oxidative Stress in Patients With PAD

2019-09-19 03:56:38 | BioPortfolio

Summary

MicroRNA-210 (miR-210) can be a potential therapeutic target of patients with peripheral artery disease (PAD). Recent evidence suggests the role of miR-210 and oxidative stress in the pathophysiology of PAD and its association with mitochondrial function, oxidative metabolism, walking distances and quality of life. The protocol evaluates the mechanisms which miR-210 regulates oxidative stress and provides evidence of potential therapeutic strategies.

Description

The investigators will randomize 180 PAD patients that undergoing a revascularization operation in two groups: (1) an endovascular procedure or (2) an open bypass procedure. They are also planing to recruit 50 non-PAD healthy control subjects.

The goal is to answer the main hypothesis that miR-210 gene expression is a master regulator of oxidative stress and is associated with mitochondrial dysfunction, oxidative metabolism, walking function and quality of life.

Study Design

Conditions

Peripheral Arterial Disease

Intervention

Revascularization operation, Control group

Location

Capital Regional Medical Center
Tallahassee
Florida
United States
32308

Status

Recruiting

Source

Florida State University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-19T03:56:38-0400

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