Nitrous Oxide for Pain Management During IUD Insertion in Nulliparous Adolescent Women

2019-09-19 03:56:39 | BioPortfolio


This study evaluates if nitrous oxide (commonly known as "laughing gas") improves the experience of intrauterine device (IUD) insertion for adolescent and young adult women. Half of participants will receive inhaled nitrous oxide during their IUD insertion, while the other half will receive a placebo (inhaled oxygen). All participants will receive ibuprofen before the IUD procedure.


The objective of this research study is to learn more about how to make the intrauterine device (IUD) insertion procedure more comfortable.

IUDs are highly effective at preventing pregnancy and are also used to treat gynecological conditions such as endometriosis or heavy periods. Unfortunately, many adolescents and young adults do not get an IUD because they are fearful that the procedure will be painful. Currently, there are no medications that successfully reduce pain during IUD insertion for adolescents in the outpatient clinic setting.

In our study, the investigators plan to study if nitrous oxide (commonly known as "laughing gas") improves the experience of IUD insertion for adolescent and young adult women. Although nitrous oxide is already used frequently to manage pain and anxiety during other procedures (such as dental work or treating injuries in the emergency room), nitrous oxide has not yet been studied for IUD insertion in teenagers and young adults.

This study will help clinicians to understand whether or not nitrous oxide could be an effective way to manage discomfort and anxiety for adolescents undergoing IUD placement. Ultimately, it is hoped that this study will lead to increased use of this highly effective method of contraception among adolescents.

Study Design


Contraceptive Devices


Nitrous oxide gas for inhalation, Oxygen Gas for Inhalation


Boston Children's Hospital
United States


Not yet recruiting


Boston Children’s Hospital

Results (where available)

View Results


Published on BioPortfolio: 2019-09-19T03:56:39-0400

Clinical Trials [2077 Associated Clinical Trials listed on BioPortfolio]

Effects of Combined Sevoflurane and Nitrous Oxide Inhalation - 14

The purpose of this study is to determine the effects of combined sevoflurane and nitrous oxide inhalation on mood, psychomotor performance, and the pain response in humans.

The Interest of the Nitrous Oxide During Intravesical Injection of Botulinum Toxin A

Second line treatment for detrusor hyperreflexia is the intravesical BTX-A injections. First 300 units Botox are diluted with 30 ml of preservative-free saline. Using a rigid cystoscope an...

Nitrous Oxide for the Treatment of Complex Regional Pain Syndrome

Patients will then be randomized via a web-based randomization system Redcap without stratification to either the nitrous oxide study group or the oxygen control group. The nitrous oxide ...

Network-Level Effects of Nitrous Oxide in the Human Brain

The purpose of this study is to understand how a commonly used drug, nitrous oxide, acts on the brain to reduce pain. Nitrous oxide is commonly used in anesthesiology but there is limited ...

Inhaled Nitrous Oxide for Treatment-Resistant Depression: Optimizing Dosing Strategies

Most clinical major depression responds to standard treatments (medication and psychotherapy); however, a significant subset of depressed patients (15-20%) do not respond to these treatmen...

PubMed Articles [8614 Associated PubMed Articles listed on BioPortfolio]

Reaction times of children having nitrous oxide inhalation sedation for dental procedures.

Inhalation sedation (IHS), using nitrous oxide and oxygen, is a commonly used form of pharmacological behaviour management in paediatric dentistry. Previous studies suggest that IHS causes a delay in ...

Subacute Combined Degeneration Caused by Nitrous Oxide Intoxication: A Report of Two Cases.

We report two cases of subacute combined degeneration (SCD) caused by nitrous oxide (N2O) gas intoxication, which is rarely reported in Korea. Two patients recreationally inhaled N2O gas daily for sev...

The discovery and development of inhaled therapeutics for migraine.

Migraine is a disabling primary headache disorder that requires effective treatments. Inhalation is currently being explored for the delivery of drugs for migraine. Pulmonary-route delivery of drugs s...

George Washington Frost Mellen and Resuscitation with Nitrous Oxide in 1847.

In The Boston Medical and Surgical Journal of 1847 (later to be called The New England Journal of Medicine), Boston chemist George Washington Frost Mellen claimed that inhaled nitrous oxide gas suppor...

Real-life budesonide and formoterol dose emission from the medium and high strength fixed dosed combinations in a Spiromax® dry powder inhaler using inhalation profiles from patients with chronic obstructive pulmonary disease.

Dry powder inhalers (DPIs) are passive devices used to administer inhaled medication for the management of asthma and chronic obstructive pulmonary disease (COPD). DPIs require patients to generate a ...

Medical and Biotech [MESH] Definitions

A neuropathy due to VITAMIN B 12 DEFICIENCY or to excessive NITROUS OXIDE inhalation. It is associated with overproduction of the myelinolytic TUMOR NECROSIS FACTOR-ALPHA.

Inhalation of oxygen aimed at restoring toward normal any pathophysiologic alterations of gas exchange in the cardiopulmonary system, as by the use of a respirator, nasal catheter, tent, chamber, or mask. (From Dorland, 27th ed & Stedman, 25th ed)

An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be administered with NITROUS OXIDE to achieve a relatively light level of anesthesia, and a neuromuscular blocking agent given concurrently to obtain the desired degree of muscular relaxation. (From AMA Drug Evaluations Annual, 1994, p180)

Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.

A variety of devices used in conjunction with METERED DOSE INHALERS. Their purpose is to hold the released medication for inhalation and make it easy for the patients to inhale the metered dose of medication into their lungs.

More From BioPortfolio on "Nitrous Oxide for Pain Management During IUD Insertion in Nulliparous Adolescent Women"

Quick Search

Relevant Topics

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...

Obstetrics and gynaecology
Fertility Menopause Obstetrics & Gynaecology Osteoporosis Women's Health Obstetrics and gynaecology comprises the care of the pregnant woman, her unborn child and the management of diseases specific to women. Most consultant...

Searches Linking to this Trial