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A Study of PRT811 in Participants With Advanced Solid Tumors, Gliomas and Myelofibrosis

2019-09-18 03:27:31 | BioPortfolio

Summary

This is a Phase 1 dose-escalation study of PRT811, a protein arginine N-methyltransferase (PRMT) 5 inhibitor, in subjects with advanced cancers, high-grade gliomas and myelofibrosis who have exhausted available treatment options. The purpose of this study is to define a safe dose and schedule to be used in subsequent development of PRT811.

Description

This is a multicenter, open-label, dose-escalation, dose-expansion Phase 1 study of PRT811, a PRMT5 inhibitor, in subjects with advanced cancers without any approved or available treatment options including solid tumors and /or high-grade gliomas, and relapsed/refractory myeloproliferative neoplasms [MPN]. The study will consist of 2 parts, a dose escalation part evaluating subjects with advanced solid tumors and/or high-grade glioma and a cohort expansion part which will evaluate the safety and efficacy of PRT811 in subjects with advanced solid tumors, glioblastoma multiforme and myelofibrosis. For subjects, the study will include a screening phase, a treatment phase, and a post treatment follow-up phase. An end-of-study visit will be conducted within 30 days after the last dose of PRT811.

Study Design

Conditions

Advanced Solid Tumor

Intervention

PRT811

Location

Sarah Cannon Research Institute at HealthONE
Denver
Colorado
United States
80218

Status

Not yet recruiting

Source

Prelude Therapeutics

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-18T03:27:31-0400

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