Insulin Resistance in Adolescents

2019-09-15 03:11:10 | BioPortfolio


The growing population of adolescents with insulin resistance (IR) is predicted to create a large public health burden in the next few decades. This study examines the function of brain blood vessels and cognitive function, to test if increasing severity of IR in adolescents is related to reduced cognitive function and reduced brain blood vessel function. Findings from this study may help create treatments to delay or prevent some of the negative effects of IR on cognitive and vascular health.


One in five American adolescents are obese, and many of these patients exhibit some level of insulin resistance (IR). IR is associated with cerebrovascular disease, reduced memory, attention, and cognition, but how IR contributes to these in the course of adolescent brain development is unclear. The goal of this proposal is to investigate the extent and by which IR drives reductions in neurocognitive function and cerebral blood flow (CBF) in adolescents at elevated risk for poor brain and cerebrovascular health. The overall goal of this research program is to investigate IR-related changes in neurocognitive and vascular function. The investigators propose to study adolescents across a spectrum of IR, from healthy to pre-diabetic, without confounding effects of age or diabetes— before the negative effects of IR can exert their full negative impact. The general hypothesis is that cognitive and vascular function is impaired via shift away from insulin-mediated vasodilation in brain blood vessels.

Study Design


Insulin Resistance


Oral Glucose Tolerance Test, 3 Tesla MRI, Intravenous Catheter, Cognitive Tests


University of Wisconsin-Madison
United States




University of Wisconsin, Madison

Results (where available)

View Results


Published on BioPortfolio: 2019-09-15T03:11:10-0400

Clinical Trials [5580 Associated Clinical Trials listed on BioPortfolio]

Glucose Tolerance in Children With Cystic Fibrosis

The aim is to describe the association of glucose tolerance measured with three different tools (continuous glucose measurement system - CGMS, oral glucose tolerance testing - OGTT and opt...

Insulin Sensitivity and Metabolomics During Oral Administration of Glucose and Graded Intravenous Infusion

Bariatric surgery has been proven to be an effective treatment of type 2 diabetes and it has highlighted to role of the small intestine in glucose homeostasis. Improvement of glucose homeo...

Women With Minor Degrees of Glucose Intoleranceand the Postpartum Glucose Tolerance Test

The aim of this study is to offer a 75g postpartum glucose tolerance test to women with minor degrees of glucose intolerance and to assess if these women are significantly different from w...

Metabolic Response to Fat and Glucose

The study will compare plasma and urine post-prandial metabolomics after fat and glucose oral load according to lifestyle factors.

The Use of Home Oral Glucose Tolerance Test Kit in Screening Cystic Fibrosis Related Diabetes

The aim of this study is to establish if the self-administered electronic Oral Glucose Tolerance Test kit can increase the annual uptake of screening for CFRD in children who are between 1...

PubMed Articles [18100 Associated PubMed Articles listed on BioPortfolio]

Plasma Metabolomics to Identify and Stratify Patients with Impaired Glucose Tolerance.

Impaired glucose tolerance (IGT) is one of the pre-symptomatic states of type 2 diabetes mellitus and requires an oral glucose tolerance test (OGTT) for diagnosis. Our aims were two-fold: 1) character...

Difference in the prevalence of gestational diabetes mellitus according to gestational age at 75-g oral glucose tolerance test, in Japan: The JAGS trial.

To evaluate the differences in the results of 75-g oral glucose tolerance tests (OGTTs) according to gestational age, in Japan.

Determinants Of The Growth Hormone Nadir During Oral Glucose Tolerance Test In Adults.

Growth hormone (GH) nadir (GHnadir) during oral glucose tolerance test (OGTT) is an important tool in diagnosing acromegaly, but data evaluating the need to adjust cut-offs to biological variables uti...

Effects of Different Fasting Durations on Glucose and Lipid Metabolism in Sprague Dawley Rats.

Overnight fasting of varying length is common practice when studying glucose and lipid metabolism in rats. However, prolonged fasting may influence insulin sensitivity, and it is unknown to which exte...

Clinical impact of citrate-containing tubes on the detection of glucose abnormalities by the oral glucose tolerance test.

Background Plasma glucose levels provide the cornerstone of diabetes evaluation, and so it is crucial that clinical laboratories provide accurate and reliable plasma glucose results. To prevent in vit...

Medical and Biotech [MESH] Definitions

A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).

A pathological state in which BLOOD GLUCOSE level is less than approximately 140 mg/100 ml of PLASMA at fasting, and above approximately 200 mg/100 ml plasma at 30-, 60-, or 90-minute during a GLUCOSE TOLERANCE TEST. This condition is seen frequently in DIABETES MELLITUS, but also occurs with other diseases and MALNUTRITION.

A neuropsychological test designed to assess different memory functions. It may incorporate an optional cognitive exam (Brief Cognitive Status Exam) that helps to assess memory related cognitive function.

A measure of a patient's ability to break down lactose.

Placement of an intravenous catheter in the subclavian, jugular, or other central vein for central venous pressure determination, chemotherapy, hemodialysis, or hyperalimentation.

More From BioPortfolio on "Insulin Resistance in Adolescents"

Quick Search

Relevant Topic

Public Health
Alternative Medicine Cleft Palate Complementary & Alternative Medicine Congenital Diseases Dentistry Ear Nose & Throat Food Safety Geriatrics Healthcare Hearing Medical Devices MRSA Muscular Dyst...

Searches Linking to this Trial