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Insulin Resistance in Adolescents

2019-09-15 03:11:10 | BioPortfolio

Summary

The growing population of adolescents with insulin resistance (IR) is predicted to create a large public health burden in the next few decades. This study examines the function of brain blood vessels and cognitive function, to test if increasing severity of IR in adolescents is related to reduced cognitive function and reduced brain blood vessel function. Findings from this study may help create treatments to delay or prevent some of the negative effects of IR on cognitive and vascular health.

Description

One in five American adolescents are obese, and many of these patients exhibit some level of insulin resistance (IR). IR is associated with cerebrovascular disease, reduced memory, attention, and cognition, but how IR contributes to these in the course of adolescent brain development is unclear. The goal of this proposal is to investigate the extent and by which IR drives reductions in neurocognitive function and cerebral blood flow (CBF) in adolescents at elevated risk for poor brain and cerebrovascular health. The overall goal of this research program is to investigate IR-related changes in neurocognitive and vascular function. The investigators propose to study adolescents across a spectrum of IR, from healthy to pre-diabetic, without confounding effects of age or diabetes— before the negative effects of IR can exert their full negative impact. The general hypothesis is that cognitive and vascular function is impaired via shift away from insulin-mediated vasodilation in brain blood vessels.

Study Design

Conditions

Insulin Resistance

Intervention

Oral Glucose Tolerance Test, 3 Tesla MRI, Intravenous Catheter, Cognitive Tests

Location

University of Wisconsin-Madison
Madison
Wisconsin
United States
53706

Status

Recruiting

Source

University of Wisconsin, Madison

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-15T03:11:10-0400

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