A Study of Toca 511 & Toca FC in Patients With Recurrent High Grade Non-Muscle Invasive Bladder Cancer (Toca 8)

2019-09-17 02:47:14 | BioPortfolio


This is a Phase 1, multicenter, open-label study of intravesical Toca 511 followed by oral Toca FC in patients with high grade (HG) non-muscle invasive bladder cancer (NMIBC), with cohort expansion at the recommended Phase 2 dose. Patients with recurrent HG NMIBC who are undergoing planned transurethral resection of bladder tumor (TURBT) will be enrolled into the study, subject to meeting all entry criteria.

Study Design


Bladder Cancer


Toca 511, Toca FC (extended-release formulation of flucytosine)


Not yet recruiting


Tocagen Inc.

Results (where available)

View Results


Published on BioPortfolio: 2019-09-17T02:47:14-0400

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PubMed Articles [19879 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

Tumors or cancer of the URINARY BLADDER.

A HERNIA-like condition in which the weakened pelvic muscles cause the URINARY BLADDER to drop from its normal position. Fallen urinary bladder is more common in females with the bladder dropping into the VAGINA and less common in males with the bladder dropping into the SCROTUM.

Involuntary discharge of URINE as a result of physical activities that increase abdominal pressure on the URINARY BLADDER without detrusor contraction or overdistended bladder. The subtypes are classified by the degree of leakage, descent and opening of the bladder neck and URETHRA without bladder contraction, and sphincter deficiency.

A fluorinated cytosine analog that is used as an antifungal agent.

An abnormal passage in the URINARY BLADDER or between the bladder and any surrounding organ.

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