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Effect of a Dietary Intervention on Intracellular Lipid, Insulin Sensitivity, and Glycemic Control in Type 2 Diabetes

2019-09-17 02:47:15 | BioPortfolio

Summary

The purpose of this study is to evaluate the effects of a plant-based diet and a portion-controlled diet on weight, muscle and liver fat content, total and LDL ("bad") cholesterol, insulin sensitivity, and metabolism (your body's use of calories) after meals.

Description

Using a cross-over design, participants with type 2 diabetes will be randomly assigned to start with a plant-based or a portion-controlled diet for 22 weeks. The two groups will then switch to the opposite diet regimen for an additional 22 weeks. Before and after each intervention period, the investigators will measure intramuscular and liver fat content and assess their relationship with insulin sensitivity and glycemic control. We hypothesize that both diets will result in reductions in intramuscular and liver fat content and that these changes will be associated with improvements in insulin sensitivity and glycemic control in individuals with type 2 diabetes. We further hypothesize that a plant-based diet will elicit greater changes in intracellular lipid concentration, compared with a portion-controlled diet.

Study Design

Conditions

Diabetes Mellitus, Type 2

Intervention

Dietary intervention

Status

Not yet recruiting

Source

Physicians Committee for Responsible Medicine

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-17T02:47:15-0400

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Medical and Biotech [MESH] Definitions

A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.

The time period before the development of symptomatic diabetes. For example, certain risk factors can be observed in subjects who subsequently develop INSULIN RESISTANCE as in type 2 diabetes (DIABETES MELLITUS, TYPE 2).

A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.

A type of diabetes mellitus that is characterized by severe INSULIN RESISTANCE and LIPODYSTROPHY. The latter may be generalized, partial, acquired, or congenital (LIPODYSTROPHY, CONGENITAL GENERALIZED).

A life-threatening complication of diabetes mellitus, primarily of TYPE 1 DIABETES MELLITUS with severe INSULIN deficiency and extreme HYPERGLYCEMIA. It is characterized by excessive LIPOLYSIS, oxidation of FATTY ACIDS, production of KETONE BODIES, a sweet smell to the breath (KETOSIS;) DEHYDRATION; and depressed consciousness leading to COMA.

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