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CD22-CAR T Cells in Children and Young Adults With B Cell Malignancies

2019-09-18 03:27:35 | BioPortfolio

Summary

The primary purpose of this study is to test whether CD22-CAR T cells can be successfully made from immune cells collected from pediatric and young adult subjects with relapsed/refractory B-cell malignancies (leukemia and lymphoma). Another purpose of this study is to test the safety and cancer killing ability of a cell therapy against a new cancer target (CD22).

Description

PRIMARY OBJECTIVE:

- Determine the feasibility of manufacturing CD22 CAR T cells for administration to children and young adults with relapsed/refractory (R/R) CD22 expressing B-cell ALL or lymphoma using the Miltenyi CliniMACS Prodigy system.

- Determine the safety of an established dose of CD22-CAR T cells in children and young adults with R/R CD22 expressing B-cell malignancies.

SECONDARY OBJECTIVE:

- Assess the clinical activity of CD22-CAR T cells in children and young adults with R/R CD22 expressing B-cell malignancies, including overall survival (OS) and progression free survival (PFS).

Study Design

Conditions

B Cell Lymphoma

Intervention

Fludarabine, Cyclophosphamide, Autologous CD22 CAR T

Location

Stanford Medical Center
Stanford
California
United States
94304

Status

Not yet recruiting

Source

Stanford University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-18T03:27:35-0400

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