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VNS-supplemented Motor Retraining After Stroke

2019-09-19 03:56:49 | BioPortfolio

Summary

The goal of this study is to learn more about the connections between the brain, spinal cord, and muscles and how these connections can be strengthened after neurological injury.

Description

To establish a link between the physiological mechanisms driving enhanced motor control in response to VNS, subjects will undergo progressive training on a visuomotor task that requires fine gradation of voluntary motor output to control a moving object through target boundaries. In separate groups, VNS or sham stimulation will be paired with movement when a minimal time-on-target (ToT) is achieved.

Study Design

Conditions

Stroke, Acute

Intervention

Training, Vagus Nerve Stimulation, Sham Stimulation

Location

University of Pittsburgh
Pittsburgh
Pennsylvania
United States
15213

Status

Not yet recruiting

Source

University of Pittsburgh

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-19T03:56:49-0400

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Medical and Biotech [MESH] Definitions

An adjunctive treatment for PARTIAL EPILEPSY and refractory DEPRESSION that delivers electrical impulses to the brain via the VAGUS NERVE. A battery implanted under the skin supplies the energy.

Stimulation of the brain, which is self-administered. The stimulation may result in negative or positive reinforcement.

The electrical response evoked in a muscle or motor nerve by electrical or magnetic stimulation. Common methods of stimulation are by transcranial electrical and TRANSCRANIAL MAGNETIC STIMULATION. It is often used for monitoring during neurosurgery.

Traumatic injuries to the VAGUS NERVE. Because the vagus nerve innervates multiple organs, injuries in the nerve fibers may result in any gastrointestinal organ dysfunction downstream of the injury site.

Stimulation at an intensity below that where a differentiated response can be elicited.

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