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VNS-induced Corticospinal Plasticity

2019-09-19 03:56:49 | BioPortfolio

Summary

The goal of this study is to learn more about the connections between the brain, spinal cord, and muscles and how these connections can be strengthened after neurological injury.

Description

Non-invasive stimulation techniques can be used to appropriately time converging inputs to induce changes in cortical output circuits of human primary motor cortex, a neuromodulatory protocol known as paired-associative stimulation (PAS). Experiments seek to examine interactions between cortical PAS and non-invasive vagus nerve stimulation (VNS) to understand the extent to which VNS amplifies cortical plasticity in humans.

Study Design

Conditions

Stroke

Intervention

Paired-Associative Stimulation (PAS), Vagus Nerve Stimulation (VNS), Sham Stimulation

Location

University of Pittsburgh
Pittsburgh
Pennsylvania
United States
15213

Status

Not yet recruiting

Source

University of Pittsburgh

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-09-19T03:56:49-0400

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Medical and Biotech [MESH] Definitions

Stimulation of the brain, which is self-administered. The stimulation may result in negative or positive reinforcement.

An adjunctive treatment for PARTIAL EPILEPSY and refractory DEPRESSION that delivers electrical impulses to the brain via the VAGUS NERVE. A battery implanted under the skin supplies the energy.

The electrical response evoked in a muscle or motor nerve by electrical or magnetic stimulation. Common methods of stimulation are by transcranial electrical and TRANSCRANIAL MAGNETIC STIMULATION. It is often used for monitoring during neurosurgery.

Stimulation at an intensity below that where a differentiated response can be elicited.

A technique of brain electric stimulation therapy which uses constant, low current delivered via ELECTRODES placed on various locations on the scalp.

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