TRAIN-BW: Backward Walking Training in Multiple Sclerosis

2019-09-20 03:46:40 | BioPortfolio


Individuals with multiple sclerosis (MS) experience in impairments in mobility and cognition that increase the risk for accidental falls. More than 50% of individuals with MS experience injurious falls within a 6-month period. Current interventions to improve fall risk have focused on forward walking (FW) and balance training, resulting in small declines in the relative risk for falls with a large degree of variability. Interestingly, motor differences between MS and healthy controls are more pronounced in backward walking (BW), yet no studies have investigated BW training as an intervention to reduce fall risk in persons with MS. Further, the underlying pathological and cognitive factors that impact BW performance and its potential to impact fall risk in persons with MS remain unknown. This study will investigate the feasibility, acceptability and impact of BW training compared to forward walking training on motor function, brain structure, and fall risk in persons with MS.

Study Design


Multiple Sclerosis


Backward Walking Training, Forward Walking Training


Not yet recruiting


Wayne State University

Results (where available)

View Results


Published on BioPortfolio: 2019-09-20T03:46:40-0400

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Medical and Biotech [MESH] Definitions

An activity in which the body advances at a slow to moderate pace by moving the feet in a coordinated fashion. This includes recreational walking, walking for fitness, and competitive race-walking.

The rate at which steps are made while walking.

Financial support for training including both student stipends and loans and training grants to institutions.

A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)

On the job training programs for personnel carried out within an institution or agency. It includes orientation programs.

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