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Urinary incontinence (UI) is a very common condition affecting women of all ages. The objective of this pilot study is to better understand the urinary microbiome and associated inflammatory markers in blood and urine in women with urgency UI. The study will assess how inflammation may affect response to standard of care anticholinergic medication treatment for urgency urinary incontinence.
This study is designed as a prospective pilot study of women presenting to the Urogynecology clinic with urgency urinary incontinence symptoms who are offered treatment with a standard of care anticholinergic medication for six weeks. The patient will be asked to provide a clean catch urine sample and blood draw. Study participants will fill out a Urinary Distress Inventory-6 (UDI-6) questionnaire at baseline and keep a bladder diary before starting the anticholinergic medication.
The urine will be assessed by enhanced urine cultures and DNA sequencing for urinary microbiome along with inflammatory mediators in the urine. Inflammatory mediators in both the blood and urine will be measured using immuonenzyme assays.
Measurements for microbiome will be repeated for all patients at 6 weeks. Baseline urinary symptoms at enrollment and variation of symptoms after 6 weeks of anticholinergic treatment will be assessed using the UDI-6 questionnaire and a bladder diary.
Oxybutynin, Solifenacin, Tolterodine, Sanctura or Toviaz
Not yet recruiting
Brigham and Women's Hospital
Published on BioPortfolio: 2019-09-20T03:46:49-0400
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